The effects of a functionally-graded scaffold and bone marrow-derived mononuclear cells on steroid-induced femoral head osteonecrosis.
The effects of a functionally-graded scaffold and bone marrow-derived mononuclear cells on steroid-induced femoral head osteonecrosis.
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DOI：
10.1016/j.biomaterials.2018.09.030
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发表时间：
2018-12
期刊：
影响因子：
14
通讯作者：
Yang YP
中科院分区：
文献类型：
--
作者：
Maruyama M;Nabeshima A;Pan CC;Behn AW;Thio T;Lin T;Pajarinen J;Kawai T;Takagi M;Goodman SB;Yang YP
股骨头坏死(ONFH)是一种衰弱的疾病，可进展为股骨头塌陷，随后发展为退行性关节炎。虽然骨髓源性单个核细胞(BMMCs)的注射在ONFH的早期阶段经常伴随核心减压(CD)进行，但这些治疗方法在防止疾病进展和股骨头塌陷方面并不总是有效的。我们之前描述了一种新型的3D打印、定制的功能梯度支架(FGS)，通过提供结构和机械指导，改善了CD后正常健康兔股骨头的骨生长。本研究在兔激素性骨坏死模型上证实了FGS的类似结果。此外，骨髓间充质干细胞注入CD减少了股骨头内的骨坏死面积。因此，FGS和BMMC的结合提供了一种新的治疗方式，通过提供增强的生物和生物力学线索来促进骨坏死区的骨再生，从而改善CD对早期ONFH的预后。
Osteonecrosis of the femoral head (ONFH) is a debilitating disease that may progress to femoral head collapse and subsequently, degenerative arthritis. Although injection of bone marrow-derived mononuclear cells (BMMCs) is often performed with core decompression (CD) in the early stage of ONFH, these treatments are not always effective in prevention of disease progression and femoral head collapse. We previously described a novel 3D printed, customized functionally-graded scaffold (FGS) that improved bone growth in the femoral head after CD in a normal healthy rabbit, by providing structural and mechanical guidance. The present study demonstrates similar results of the FGS in a rabbit steroid-induced osteonecrosis model. Furthermore, the injection of BMMCs into the CD decreased the osteonecrotic area in the femoral head. Thus, the combination of FGS and BMMC provides a new therapy modality that may improve the outcome of CD for early stage of ONFH by providing both enhanced biological and biomechanical cues to promote bone regeneration in the osteonecrotic area.
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