Systematic characterization of 3D-printed PCL/β-TCP scaffolds for biomedical devices and bone tissue engineering: influence of composition and porosity.
Systematic characterization of 3D-printed PCL/β-TCP scaffolds for biomedical devices and bone tissue engineering: influence of composition and porosity.
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DOI：
10.1557/jmr.2018.112
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发表时间：
2018-07-27
影响因子：
2.7
通讯作者：
Yang YP
中科院分区：
文献类型：
--
作者：
Bruyas A;Lou F;Stahl AM;Gardner M;Maloney W;Goodman S;Yang YP
这项工作旨在通过系统的实验表征为潜在骨科应用的3D打印支架设计提供指导，重点是使用临床可用的聚己内酯（PCL）和β-磷酸三钙（β-TCP）的复合材料进行熔融沉积建模（FDM）。首先，我们研究了化学组成（0%-60% β-TCP/PCL）对支架性能的影响。结果表明，表面粗糙度和接触角分别与β-TCP含量成正比和反比，降解速率随陶瓷含量的增加而增加。在生物学上，β-TCP的加入促进了C3 H10的增殖和成骨分化。其次，我们系统地研究了组成和孔隙率对3D打印支架力学性能的影响。增加β-TCP的量和降低孔隙率都增加了3D打印支架的表观杨氏模量。第三，作为概念验证，设计并制造了一种新型的多材料仿生植入物，用于潜在的椎间盘置换。
This work aims at providing guidance through systematic experimental characterization, for the design of 3D printed scaffolds for potential orthopaedic applications, focusing on fused deposition modeling (FDM) with a composite of clinically available polycaprolactone (PCL) and β-tricalcium phosphate (β-TCP). First, we studied the effect of the chemical composition (0% to 60% β-TCP/PCL) on the scaffold's properties. We showed that surface roughness and contact angle were respectively proportional and inversely proportional to the amount of β-TCP, and that degradation rate increased with the amount of ceramic. Biologically, the addition of β-TCP enhanced proliferation and osteogenic differentiation of C3H10. Secondly, we systematically investigated the effect of the composition and the porosity on the 3D printed scaffold mechanical properties. Both an increasing amount of β-TCP and a decreasing porosity augmented the apparent Young's modulus of the 3D printed scaffolds. Third, as a proof-of-concept, a novel multi-material biomimetic implant was designed and fabricated for potential disk replacement.
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影响因子：
2.4
作者：
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通讯作者：
GIBSON, LJ
影响因子：
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作者：
Yeo, A.;Rai, B.;Teoh, S. H.
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DOI：
10.1016/j.msec.2006.05.006
发表时间：
2007-03-01
期刊：
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
影响因子：
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作者：
Lei, Y.;Rai, B.;Teoh, S. H.
通讯作者：
Teoh, S. H.
DOI：
10.1016/j.esas.2011.05.001
发表时间：
2011-01-01
期刊：
SAS journal
影响因子：
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作者：
Serhan, Hassan;Mhatre, Devdatt;Bono, Christopher M
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Bono, Christopher M