Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape.

Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape.
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结核病 DNA 疫苗递送中的纳米材料:历史视角和当前景观。

DOI:
10.1080/10717544.2022.2120565
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发表时间:
2022-12
期刊:
影响因子:
6
通讯作者:
--
中科院分区:
医学2区
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--
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接种疫苗,特别是促进宿主免疫的DNA疫苗,是控制结核病最有效的干预措施。然而,疫苗递送系统对疫苗的保护作用有显著影响。最近,为控制结核病的DNA疫苗开发了有效的基于纳米材料的递送系统(包括纳米颗粒、纳米金、纳米脂质体、病毒样颗粒和病毒载体)。这篇综述强调了各种基于纳米材料的结核病DNA疫苗递送系统的历史发展,以及新兴技术。基于纳米材料的疫苗递送系统可以提高结核病疫苗接种的效力;因此,这一总结可以指导纳米材料的选择,以实现最佳和安全的疫苗递送,促进高效结核病疫苗的设计和开发。
Vaccinations, especially DNA vaccines that promote host immunity, are the most effective interventions for tuberculosis (TB) control. However, the vaccine delivery system exhibits a significant impact on the protective effects of the vaccine. Recently, effective nanomaterial-based delivery systems (including nanoparticles, nanogold, nanoliposomes, virus-like particles, and virus carriers) have been developed for DNA vaccines to control TB. This review highlights the historical development of various nanomaterial-based delivery systems for TB DNA vaccines, along with the emerging technologies. Nanomaterial-based vaccine delivery systems could enhance the efficacy of TB vaccination; therefore, this summary could guide nanomaterial selection for optimal and safe vaccine delivery, facilitating the design and development of highly effective TB vaccines.
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