Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1).
Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1).
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DOI：
10.1359/jbmr.090723
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Yakar S
中科院分区：
文献类型：
--
作者：
Fritton JC;Emerton KB;Sun H;Kawashima Y;Mejia W;Wu Y;Rosen CJ;Panus D;Bouxsein M;Majeska RJ;Schaffler MB;Yakar S
绝经后妇女雌激素丧失和动物卵巢切除（OVX）后早期，骨内骨吸收加速导致长骨干的骨髓扩张，从而降低机械完整性。生长激素 (GH) 和胰岛素样生长因子 (IGF-1) 都是骨重塑过程的有效调节剂。为了研究 GH/IGF-1 轴在雌激素缺乏中的作用，我们使用了肝脏 IGF-1 缺陷 (LID) 小鼠。与对照组的缺陷相反，LID小鼠的OVX导致皮质骨机械完整性的维持，这主要是由于骨膜扩张对横截面结构（总面积和皮质宽度）的影响增强。 LID 中的血清平衡有利于 GH 而不是 IGF-1，从而减少了卵巢功能消融对骨髓中破骨细胞前体数量和皮质基质内骨细胞活力的影响，除了增加骨膜骨形成外，还导致骨内膜吸收减少。雌激素和 GH/IGF-1 系统之间与骨重塑相关的相互作用提供了一条尽量减少骨组织结构退化和骨质疏松性骨折的途径。 © 2010 美国骨与矿物质研究学会
Early after estrogen loss in postmenopausal women and ovariectomy (OVX) of animals, accelerated endosteal bone resorption leads to marrow expansion of long bone shafts that reduce mechanical integrity. Both growth hormone (GH) and insulin-like growth factor (IGF-1) are potent regulators of bone remodeling processes. To investigate the role of the GH/IGF-1 axis with estrogen deficiency, we used the liver IGF-1-deficient (LID) mouse. Contrary to deficits in controls, OVX of LID mice resulted in maintenance of cortical bone mechanical integrity primarily owing to an enhanced periosteal expansion affect on cross-sectional structure (total area and cortical width). The serum balance in LID that favors GH over IGF-1 diminished the effects of ablated ovarian function on numbers of osteoclast precursors in the marrow and viability of osteocytes within the cortical matrix and led to less endosteal resorption in addition to greater periosteal bone formation. Interactions between estrogen and the GH/IGF-1 system as related to bone remodeling provide a pathway to minimize degeneration of bone tissue structure and osteoporotic fracture. © 2010 American Society for Bone and Mineral Research
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影响因子：
4
作者：
Hawse, J. R.;Subramaniam, M.;Spelsberg, T. C.
通讯作者：
Spelsberg, T. C.
影响因子：
5.8
作者：
Gibney, J;Johannsson, G;Ho, KKY
通讯作者：
Ho, KKY
影响因子：
2.5
作者：
Jepsen, KJ;Akkus, O;Nadeau, JH
通讯作者：
Nadeau, JH
DOI：
10.1073/pnas.0308744101
发表时间：
2004-03-02
影响因子：
11.1
作者：
Elefteriou, F;Takeda, S;Karsenty, G
通讯作者：
Karsenty, G
影响因子：
56.9
作者：
HAYES, WC
通讯作者：
HAYES, WC