The incidence and prognosis of thromboembolism associated with oral contraceptives: Age-dependent difference in Japanese population.
The incidence and prognosis of thromboembolism associated with oral contraceptives: Age-dependent difference in Japanese population.
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DOI：
10.1111/jog.13706
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Kobayashi T
中科院分区：
文献类型：
--
作者：
Sugiura K;Ojima T;Urano T;Kobayashi T
我们分析了日本各年龄组与联合口服避孕药（COCs）相关的血栓栓塞的发生率和预后。我们分析了2004年至2013年美国药品和医疗器械管理局数据库中与COCs相关的581例静脉血栓栓塞（VTE）和动脉血栓栓塞（ATE）事件。在统计分析中，预后良好组包括康复病例，而预后差组包括未康复的病例，并有一些后遗症和死亡病例。采用Pearson卡方检验计算两组患者预后差异，采用Cochran-Armitage趋势检验两组患者不同激素避孕药预后差异的年龄特异性趋势和趋势。共分析了543例事件，其中年龄未知的事件38例最为常见，其次是脑梗死、PE合并DVT、PE单独、脑静脉血栓形成。随着年龄的增长，整体血栓栓塞的ATE比率有增加的趋势（P = 0.0041）。预后良好组较为常见（静脉血栓栓塞291例，ATE 83例），其次为预后不良组（静脉血栓栓塞46例，ATE 34例）。与所有VTE病例相比，所有ATE病例的预后均明显较差（P < 0.0001）。然而，孕激素类型和年龄差异在预后良好组和预后不良组之间无差异趋势（P = 0.3548和P = 0.6097）。血栓栓塞事件在40多岁时最常见。总体血栓栓塞的ATE比率随着年龄的增长而增加。与所有VTE病例相比，所有ATE病例的预后明显较差。
We analyzed the incidence and prognosis of thromboembolism associated with combined oral contraceptives (COCs) by age groups in Japan. A total of 581 events of venous thromboembolism (VTE) and arterial thromboembolism (ATE) associated with COCs were analyzed from the Pharmaceuticals and Medical Devices Agency database from 2004 to 2013. In a statistical analysis, a good‐prognosis group included recovery cases and a poor‐prognosis group involved unrecovered cases with some sequela and fatal cases. The significant difference between these two groups was calculated by Pearson's chi‐square test, and the age‐specific tendency and the trend of differences in prognosis according to different hormonal contraceptives were examined by Cochran–Armitage trend test. A total of 543 events were analyzed except 38 events due to unknown age, in which DVT only was the most frequent, followed by cerebral infarction, PE with DVT, PE only, cerebral vein thromboses. ATE ratio for overall thromboembolism tended to increase with advancing age (P = 0.0041). Good‐prognosis group was common (291 cases in VTE and 83 cases in ATE), followed by poor‐prognosis group (46 cases in VTE and 34 cases in ATE). All ATE cases had a significantly poorer prognosis in comparison with all VTE cases (P < 0.0001). Types of progestin and age difference, however, showed no trend in the differences between good‐prognosis group and poor‐prognosis group (P = 0.3548 and P = 0.6097). Thromboembolic events were the most frequent in the 40s. The ATE ratio for overall thromboembolism tended to increase with advancing age. All ATE cases had a significantly poorer prognosis in comparison with all VTE cases.
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影响因子：
2.9
作者：
Ferro, JM;Lopes, MG;Fontes, J
通讯作者：
Fontes, J
影响因子：
14.6
作者：
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通讯作者：
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DOI：
10.1136/jfprhc-2013-100624
发表时间：
2013-07-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
7.5
作者：
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