The "sacral parasympathetic": ontogeny and anatomy of a myth.

The "sacral parasympathetic": ontogeny and anatomy of a myth.
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DOI:
10.1007/s10286-017-0478-7
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发表时间:
2018-03
期刊:
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
影响因子:
--
通讯作者:
Brunet JF
Brunet JF
中科院分区:
其他
文献类型:
--
作者:
Espinosa-Medina I;Saha O;Boismoreau F;Brunet JF

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我们最近定义了区分交感神经元和副交感神经元的遗传性状,包括节前神经元和神经节神经元(Espinosa-Medina等人,Science 354:893-897)。根据这套标准,我们发现骶骨自主神经流出是交感神经的,而不是世纪以来一直认为的副交感神经的。提出这样一个迟来的观点转变引出了一个问题,为什么新的标准(由基因组成和依赖性定义的细胞类型)应该比很久以前激发“副交感神经”分类的解剖学,生理学和药理学考虑更受欢迎。在简要回顾了前者之后,我们阐述了后者的弱点,并认为新的遗传定义有助于整合被忽视的解剖学和生理学观察,并为未来的研究扫清道路。
We recently defined genetic traits that distinguish sympathetic from parasympathetic neurons, both preganglionic and ganglionic (Espinosa-Medina et al., Science 354:893–897,). By this set of criteria, we found that the sacral autonomic outflow is sympathetic, not parasympathetic as has been thought for more than a century. Proposing such a belated shift in perspective begs the question why the new criterion (cell types defined by their genetic make-up and dependencies) should be favored over the anatomical, physiological and pharmacological considerations of long ago that inspired the “parasympathetic” classification. After a brief reminder of the former, we expound the weaknesses of the latter and argue that the novel genetic definition helps integrating neglected anatomical and physiological observations and clearing the path for future research.
DOI: 10.1113/jphysiol.1985.sp015663
发表时间: 1985-01-01
影响因子: 5.5
作者:
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