Oxytocin during breastfeeding and maternal mood symptoms.
Oxytocin during breastfeeding and maternal mood symptoms.
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DOI：
10.1016/j.psyneuen.2019.104581
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发表时间：
2020-03
影响因子：
3.7
通讯作者：
Stuebe A
中科院分区：
文献类型：
--
作者：
Whitley J;Wouk K;Bauer AE;Grewen K;Gottfredson NC;Meltzer-Brody S;Propper C;Mills-Koonce R;Pearson B;Stuebe A
本研究旨在量化产后抑郁症与焦虑、催产素和母乳喂养之间的关系。我们对从妊娠晚期到产后 12 个月的母婴二人组进行了一项纵向前瞻性研究。招募了 222 名女性样本来完成贝克抑郁量表 II 和斯皮尔伯格状态特质焦虑量表状态分量表，参加产后 2 个月和 6 个月的观察婴儿喂养课程，并在喂养期间提供静脉血样本。通过提取酶免疫分析法测定经 EDTA 处理的血浆和唾液中母体静脉催产素水平，并使用曲线下面积 (AUC) 的综合测量值来定义整个母乳喂养期间的催产素。使用线性回归来估计产后抑郁和焦虑作为预测因素以及母乳喂养期间催产素 AUC 作为产后 2 个月和 6 个月的结果之间的关联。使用考虑重复催产素测量之间相关性的混合模型来量化当前抑郁和/或焦虑症状与母乳喂养期间催产素概况之间的关联。我们发现产后 2 个月或 6 个月时，抑郁或焦虑的女性与无症状的女性在喂养过程中催产素 AUC 没有显着差异。重复测量分析表明，不同症状组的母乳喂养期间催产素轨迹没有差异，但抗抑郁药物的使用可能存在差异。我们的研究表明，外部因素可能会影响催产素、母亲情绪症状和婴儿喂养之间的关系。
This study aimed to quantify the relationship between postpartum depression and anxiety, oxytocin, and breastfeeding. We conducted a longitudinal prospective study of mother-infant dyads from the third trimester of pregnancy to 12 months postpartum. A sample of 222 women were recruited to complete the Beck Depression Inventory II and Spielberger State-Trait Anxiety Inventory-state subscale, participate in observed infant feeding sessions at 2 and 6 months postpartum, and provide venous blood samples during feeding. Maternal venous oxytocin levels in EDTA-treated plasma and saliva were determined by enzyme immunoassay with extraction and a composite measure of area under the curve (AUC) was used to define oxytocin across a breastfeeding session. Linear regression was used to estimate associations between postpartum depression and anxiety as predictors and oxytocin AUC during breastfeeding as the outcome at both 2 and 6 months postpartum. Mixed models accounting for correlations between repeated oxytocin measures were used to quantify the association between current depression and/or anxiety symptoms and oxytocin profiles during breastfeeding. We found no significant differences in oxytocin AUC across a feed between depressed or anxious women and asymptomatic women at either 2 or 6 months postpartum. Repeated measures analyses demonstrated no differences in oxytocin trajectories during breastfeeding by symptom group but possible differences by antidepressant use. Our study suggests that external factors may influence the relationship between oxytocin, maternal mood symptoms, and infant feeding.
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影响因子：
25.8
作者：
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通讯作者：
Stein A
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