Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury
Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury
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在坐骨神经挤压损伤大鼠模型中，人参皂苷 Re 通过 ERK 和 JNK 依赖性途径促进雪旺细胞的增殖、分化和迁移，从而促进神经再生
DOI：
10.1007/s10571-015-0177-7
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发表时间：
2015-03
影响因子：
4
通讯作者：
Qian Tan
中科院分区：
文献类型：
--
作者：
Chun Liu;Hongbing Cheng;Yan Song;Qian Tan
探索能够促进神经再生的有效药物受到了广泛关注。人参皂苷Re是人参浆果和根部的主要成分。该领域的研究表明，人参皂苷Re具有多种药理作用。
Exploring effective drugs that are capable of promoting nerve regeneration has gained much attention. Ginsenoside Re (Re) is the main ingredient of ginseng berries and roots. Research in the area has shown that ginsenoside Re exhibits multiple pharmacological activities via different mechanisms both in vivo and in vitro. But the potential therapeutic effects of Re on sciatic nerve crush injury (SNC) have been little investigated. Herein, we investigated the protect effect of Re on peripheral nerve regeneration in a rat SNC model. Walking track analysis revealed that Re treatment significantly promoted functional recovery of crushed sciatic nerve in rats. The expression of PCNA in rat sciatic nerve was up-regulated by Re treatment, and peaked when the concentration of Re was 2.0 mg/kg. Using immunofluorescent staining, we found that Re greatly increased the expression of GAP-43 and S100 in injured rat sciatic nerve. Furthermore, we evaluated the effects of Re on proliferation, differentiation, and migration of Schwann cells in SNC rat models. Our studies reveal that Re promotes nerve regeneration is depend on ERK1/2 and JNK1/2 signaling pathway. Elevated Oct-6 expression and featured morphological changes indicated that Re facilitated the differentiation of Schwann cells following SNC. Also, transwell and wound-healing assay demonstrated that the migration capabilities of Schwann cell were significantly enhanced after Re treatment.
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影响因子：
3.3
作者：
B. Pongkitwitoon;S. Sakamoto;O. Morinaga;T. Juengwatanatrakul;Y. Shoyama;Hiroyuki Tanaka;S. Morimoto
通讯作者：
B. Pongkitwitoon;S. Sakamoto;O. Morinaga;T. Juengwatanatrakul;Y. Shoyama;Hiroyuki Tanaka;S. Morimoto
影响因子：
5.6
作者：
Chunfu Wu;X. Bi;Jing Y Yang;J. Zhan;Y. Dong;J. Wang;Ji Ming Wang;Ruiwen Zhang;Xian Li
通讯作者：
Chunfu Wu;X. Bi;Jing Y Yang;J. Zhan;Y. Dong;J. Wang;Ji Ming Wang;Ruiwen Zhang;Xian Li
红芪提取物通过增强放大效应改善周围神经损伤后的再生
影响因子：
3.7
作者：
Wang Z;Zhang P;Kou Y;Yin X;Han N;Jiang B
通讯作者：
Jiang B
影响因子：
56.9
作者：
Johnson, GL;Lapadat, R
通讯作者：
Lapadat, R
影响因子：
3.2
作者：
Deng, Xiaolong;Wei, Haixiang;Wang, Youhua
通讯作者：
Wang, Youhua