Prevalence of microalbuminuria and associated electrocardiographic abnormalities in an Indo-Asian population.
Prevalence of microalbuminuria and associated electrocardiographic abnormalities in an Indo-Asian population.
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DOI：
10.1093/ndt/gfp042
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Hashmi S
中科院分区：
文献类型：
--
作者：
Jafar TH;Qadri Z;Hashmi S
背景微量白蛋白尿（MA）是欧洲血统人群中心血管疾病（CVD）的已知预测因子，但在CVD风险较高的印度-亚洲人群中缺乏此类数据。主要心电图（ECG）变化可预测心血管死亡率。我们确定了巴基斯坦普通人群中MA与主要ECG变化的相关性。方法.来自卡拉奇12个随机选择社区的3143名年龄≥40岁的受试者参加了研究。MA定义为单点晨尿样本中尿白蛋白与肌酐（ACR）的比值< 300 mg/g肌酐，男性≥17 mg/g，女性≥25 mg/g。使用明尼苏达分类法对ECG的重大变化进行两次编码。结果受试者的平均年龄为51.5（10.7）岁。ACR中位数（25-75百分位数）男性为4.2（2.9-7.9）mg/g，女性为6.0（3.9-10.8）mg/g（P < 0.001）。MA的总体患病率（95% CI）为12.3%（11.1-13.5%），在有重大ECG变化的患者中为20.3%。在多变量模型中，主要ECG变化（OR，95% CI）（1.50，1.10-2.00），糖尿病（3.57，2.93-4.35），高血压（2.30，1.85-2.86），女性（0.61，0.53-0.69），年龄（1.09，1.05-1.13，每增加5年）和eGFR（0.80，0.78-0.81，每增加10 mg/g）与MA独立相关。MA的存在使高血压患者的主要ECG改变的患病率从21%增加到31%（44.9%），糖尿病患者的患病率从15%增加到28%（21.4%），超重或肥胖患者的患病率从14%增加到26%（68.4%），目前吸烟者的患病率从14%增加到26%（38.7%）（P < 0.001）。结论. MA与主要ECG变化之间的强相关性强调了筛查印度-亚洲受试者MA以揭示潜在CVD的重要性，特别是高血压、糖尿病、肥胖和烟草使用者。
Background. Microalbuminuria (MA) is a known predictor of cardiovascular disease (CVD) in European origin populations, but such data are lacking in native Indo-Asian populations, where CVD risks are high. Major electrocardiographic (ECG) changes are predictive of cardiovascular mortality. We determined the association of MA with major ECG changes in the general population of Pakistan. Methods. A total of 3143 subjects aged ≥40 years from 12 randomly selected communities in Karachi participated. MA was defined as the urine albumin to creatinine (ACR) ratio of < 300 mg/g creatinine and ≥17 mg/g in men and ≥25 mg/g in women from a single-spot morning urine sample. Major changes on ECG were coded in duplicate using Minnesota classification. Results. The mean age of subjects was 51.5 (10.7) years. The median (25–75 percentile) ACR was 4.2 (2.9–7.9) mg/g in men and 6.0 (3.9–10.8) mg/g in women (P < 0.001). The overall prevalence (95% CI) of MA was 12.3% (11.1–13.5%), and 20.3% in those with major ECG changes. In a multivariable model, major ECG changes (OR, 95% CI) (1.50, 1.10–2.00), diabetes (3.57, 2.93–4.35), hypertension (2.30, 1.85–2.86), female sex (0.61, 0.53–0.69), age (1.09, 1.05–1.13, for each 5-year increase) and eGFR (0.80, 0.78–0.81, for each 10 mg/g increase) were independently associated with MA. The presence of MA increased the prevalence of major ECG changes from 21 to 31% in those with hypertension (44.9%), 15 to 28% among those with diabetes (21.4%), 14 to 26% among those with overweight or obesity (68.4%) and 14 to 26% among current users of tobacco (38.7%) (P < 0.001) each. Conclusions. The strong association between MA and major ECG changes underscores the importance of screening Indo-Asian subjects for MA for unmasking underlying CVD, especially those with hypertension, diabetes, obesity, and tobacco users.
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影响因子：
2.8
作者：
Diercks, GFH;Hillege, HL;van Gilst, WH
通讯作者：
van Gilst, WH
影响因子：
3.5
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Fischbacher, CM;Bhopal, R;Alberti, KGMM
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19.6
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7.7
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