Periodontal disease and incidence of hypertension in the health professionals follow-up study.
Periodontal disease and incidence of hypertension in the health professionals follow-up study.
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DOI：
10.1038/ajh.2012.32
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发表时间：
2012-07
影响因子：
3.2
通讯作者：
Joshipura, Kaumudi J.
中科院分区：
文献类型：
--
作者：
Rivas-Tumanyan, Sona;Spiegelman, Donna;Curhan, Gary C.;Forman, John P.;Joshipura, Kaumudi J.
最近的研究表明，牙周病和高血压之间可能存在关联，但前瞻性证据有限。研究人群包括HPFS前瞻性队列的31，543名参与者，基线时年龄为40至75岁，既往无高血压病史，并有完整的口腔健康基线信息。牙周病、高血压和潜在混杂因素的信息每两年更新一次。我们使用考克斯比例风险模型来研究基线牙周病、随访期间牙周骨丢失严重程度、基线牙齿数量和随访期间牙齿丢失以及发生高血压风险之间的关系。多变量模型包括年龄、日历时间、种族、综合吸烟指数、糖尿病、饮酒、高血压家族史、牙科专业、BMI、体力活动、水果和蔬菜摄入、多种维生素使用、钙、维生素D和维生素E摄入。我们在20年的随访中确定了10，828例高血压事件。在调整了潜在的混杂因素后，我们没有观察到基线时高血压和牙周病之间的显著相关性（RR=1.04; 95%CI：0.98-1.10），随访期间牙周炎（RR=1.01; 95% CI：0.96-1.05），随访期间牙齿缺失（RR=1.03; 95% CI：0.98-1.09），或将基线时0-10颗牙齿的男性与≥25颗牙齿的男性进行比较时（RR=1.05; 95% CI：0.91-1.21）。与无骨质流失的受试者相比，报告严重牙周骨质流失的受试者发生高血压的相对风险为1.02（95%CI：0.77-1.35）。我们没有观察到牙周疾病的措施和高血压事件之间的联系，在这个队列的中年男子。
Recent studies suggest a possible association between periodontal disease and hypertension; however, prospective evidence is limited. The study population consisted of 31,543 participants of the HPFS prospective cohort who were 40 to 75 years old at baseline, had no prior hypertension history and had complete baseline information on oral health. Information on periodontal disease, hypertension and potential confounders was updated biennially. We used Cox proportional hazards models to study the relation between periodontal disease at baseline, during follow-up, periodontal bone loss severity, baseline number of teeth and tooth loss during follow-up, and the risk of developing hypertension. Multivariate models included age, calendar time, race, comprehensive smoking index, diabetes, alcohol consumption, family history of hypertension, dental profession, BMI, physical activity, fruit and vegetable intake, multivitamin use, calcium, vitamin D and vitamin E intake. We identified 10,828 cases of incident hypertension over 20 years of follow-up. After adjusting for potential confounders, we did not observe significant associations between incident hypertension and periodontal disease at baseline (RR=1.04; 95% CI: 0.98–1.10), periodontitis during follow-up (RR=1.01; 95% CI: 0.96–1.05), tooth loss during follow-up (RR=1.03; 95% CI: 0.98–1.09), or when comparing men with 0–10 teeth to men with ≥25 teeth at baseline (RR=1.05; 95% CI: 0.91–1.21). Participants reporting severe periodontal bone loss had a relative risk for incident hypertension of 1.02 compared to those without bone loss (95% CI: 0.77–1.35). We did not observe an association between periodontal disease measures and incident hypertension in this cohort of middle-aged men.
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影响因子：
4.7
作者：
Li, JJ;Fang, CH;Hui, RT
通讯作者：
Hui, RT
影响因子：
4.3
作者：
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通讯作者：
Lind, Lars
DOI：
10.1073/pnas.0710335105
发表时间：
2007-12-18
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
WILLETT, WC
影响因子：
4.3
作者：
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通讯作者：
Glynn, RJ