Development of a spiral spin- and gradient-echo (spiral-SAGE) approach for improved multi-parametric dynamic contrast neuroimaging.
Development of a spiral spin- and gradient-echo (spiral-SAGE) approach for improved multi-parametric dynamic contrast neuroimaging.
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DOI：
10.1002/mrm.28933
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发表时间：
2021-12
影响因子：
3.3
通讯作者：
Quarles, C. Chad
中科院分区：
文献类型：
--
作者：
Stokes, Ashley M.;Ragunathan, Sudarshan;Robison, Ryan K.;Fuentes, Alberto;Bell, Laura C.;Karis, John P.;Pipe, James G.;Quarles, C. Chad
本研究的目的是建立一种基于螺旋的旋转和梯度回波联合（螺旋- sage）方法，用于同时进行动态对比增强（DCE-MRI）和动态敏感性对比MRI （DSC-MRI）。利用该序列，我们获得了1.69和26 ms的梯度回波TE， 87.72 ms的SE，和1663 ms的TR。使用迭代的SENSE重建，然后去模糊，螺旋引起的图像伪影被最小化。健康志愿者的图像显示了使用优化重建的图像质量，并与基于epi的SAGE进行了比较。采用生物反应器幻影来比较螺旋sage和EPI-SAGE的动态对比时间过程。脑肿瘤患者的概念验证队列显示了使用螺旋- sage可获得的血流动力学图的范围。螺旋sage图像与传统EPI-SAGE图像的比较表明，图像失真和人工图像强度变化显著减少。生物反应器幻影数据显示，标准EPI-SAGE和螺旋- sage在第二次和第三次回波中的动态对比时间过程相似，而第一次回波数据显示，随着回声时间的缩短，T1变化的量化有所改善。在一组脑肿瘤患者中，与标准的单回波EPI灌注图相比，显示了基于螺旋sage的灌注和通透性图。通过减轻EPI通常遇到的伪影，并通过提供更短的回波时间来改善渗透性表征，Spiral-SAGE为灌注和渗透性评估提供了实质性的改进。螺旋- sage可以量化灌注、渗透性和血管结构参数，如脑肿瘤。
The purpose of this study was to develop a spiral-based combined spin- and gradient-echo (spiral-SAGE) method for simultaneous dynamic contrast-enhanced (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI). Using this sequence, we obtained gradient-echo TEs of 1.69 and 26 ms, a SE TE of 87.72 ms, with a TR of 1663 ms. Using an iterative SENSE reconstruction followed by deblurring, spiral-induced image artifacts were minimized. Healthy volunteer images are shown to demonstrate image quality using the optimized reconstruction, as well as for comparison with EPI-based SAGE. A bioreactor phantom was used to compare dynamic-contrast time courses with both spiral-SAGE and EPI-SAGE. A proof-of-concept cohort of patients with brain tumors shows the range of hemodynamic maps available using spiral-SAGE. Comparison of spiral-SAGE images with conventional EPI-SAGE images illustrates substantial reductions of image distortion and artifactual image intensity variations. Bioreactor phantom data show similar dynamic contrast time courses between standard EPI-SAGE and spiral-SAGE for the second and third echoes, whereas first-echo data show improvements in quantifying T1 changes with shorter echo times. In a cohort of patients with brain tumors, spiral-SAGE-based perfusion and permeability maps are shown with comparison with the standard single-echo EPI perfusion map. Spiral-SAGE provides a substantial improvement for the assessment of perfusion and permeability by mitigating artifacts typically encountered with EPI and by providing a shorter echo time for improved characterization of permeability. Spiral-SAGE enables quantification of perfusion, permeability, and vessel architectural parameters, as demonstrated in brain tumors.
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影响因子：
2.7
作者：
Barnes SR;Ng TS;Santa-Maria N;Montagne A;Zlokovic BV;Jacobs RE
通讯作者：
Jacobs RE
影响因子：
3.3
作者：
Johnson, G;Wetzel, SG;Tofts, PS
通讯作者：
Tofts, PS
影响因子：
3.8
作者：
Liu, Ho-Ling;Wu, Yi-Ying;Hsu, Yuan-Yu
通讯作者：
Hsu, Yuan-Yu
DOI：
10.18383/j.tom.2016.00217
发表时间：
2016-12
期刊：
Tomography (Ann Arbor, Mich.)
影响因子：
--
作者：
Paulson ES;Prah DE;Schmainda KM
通讯作者：
Schmainda KM
DOI：
10.1177/0271678x17694187
发表时间：
2017-06
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Digernes I;Bjørnerud A;Vatnehol SAS;Løvland G;Courivaud F;Vik-Mo E;Meling TR;Emblem KE
通讯作者：
Emblem KE