ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies.
ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies.
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DOI：
10.1186/s12880-015-0062-3
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发表时间：
2015-06-16
影响因子：
2.7
通讯作者：
Jacobs RE
中科院分区：
文献类型：
--
作者：
Barnes SR;Ng TS;Santa-Maria N;Montagne A;Zlokovic BV;Jacobs RE
动态对比增强磁共振成像（DCE-MRI）是一种很有前途的表征病理和评估治疗反应的技术。然而，DCE-MRI数据的分析是复杂的，并且受益于多个动力学模型和参数的并发分析。目前很少有软件工具专门针对DCE-MRI分析与多个动力学模型。在这里，我们开发了ROCKETSHIP，一个开源，灵活和模块化的软件，用于DCE-MRI分析。ROCKETSHIP结合了多种动力学模型的分析，包括数据驱动的嵌套模型分析。ROCKETSHIP使用MATLAB编程语言实现。软件的鲁棒性，以提供可靠的拟合使用多个动力学模型是通过模拟数据证明。仿真还演示了数据驱动嵌套模型分析的实用性。通过对人脑和小鼠肿瘤模型的DCE-MRI研究表明，ROCKETSHIP在临床前和临床研究中的适用性。实现了DCE-MRI软件套件，并使用模拟进行了测试。它适用于临床前和临床数据集。ROCKETSHIP被设计为易于访问的初学者，但足够灵活的变化或补充是由高级用户以及。灵活的分析工具的可用性将有助于未来使用DCE-MRI进行研究。ROCKETSHIP的公开发布可在https://github.com/petmri/ROCKETSHIP上获得。
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a promising technique to characterize pathology and evaluate treatment response. However, analysis of DCE-MRI data is complex and benefits from concurrent analysis of multiple kinetic models and parameters. Few software tools are currently available that specifically focuses on DCE-MRI analysis with multiple kinetic models. Here, we developed ROCKETSHIP, an open-source, flexible and modular software for DCE-MRI analysis. ROCKETSHIP incorporates analyses with multiple kinetic models, including data-driven nested model analysis. ROCKETSHIP was implemented using the MATLAB programming language. Robustness of the software to provide reliable fits using multiple kinetic models is demonstrated using simulated data. Simulations also demonstrate the utility of the data-driven nested model analysis. Applicability of ROCKETSHIP for both preclinical and clinical studies is shown using DCE-MRI studies of the human brain and a murine tumor model. A DCE-MRI software suite was implemented and tested using simulations. Its applicability to both preclinical and clinical datasets is shown. ROCKETSHIP was designed to be easily accessible for the beginner, but flexible enough for changes or additions to be made by the advanced user as well. The availability of a flexible analysis tool will aid future studies using DCE-MRI. A public release of ROCKETSHIP is available at https://github.com/petmri/ROCKETSHIP.
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影响因子：
6.3
作者：
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通讯作者：
Larsson, Henrik B. W.
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Ewing, James. R.
影响因子：
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