Ethanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons.
Ethanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons.
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DOI：
10.1038/s41467-018-05894-y
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发表时间：
2018-08-30
影响因子：
16.6
通讯作者：
Ikegaya Y
中科院分区：
文献类型：
--
作者：
Sakaguchi T;Iwasaki S;Okada M;Okamoto K;Ikegaya Y
酒精是一种传统的社会联结剂;然而，酒精驱动的社会行为背后的神经机制仍然难以捉摸。在这里，我们报告说，乙醇促进观察恐惧反应。观察小鼠表现出更强的防御不动性，同时观察笼接受重复的脚电击，如果观察小鼠经历了短暂的启动脚电击。这种增强与观察诱导的前扣带皮层（ACC）神经元亚群的募集有关，这些神经元对观察者小鼠自身的疼痛有反应。代理激活的ACC神经元优先向基底外侧杏仁核投射轴突。乙醇转移ACC神经元的平衡向抑制，促进优先ACC神经元的招聘在观察过程中，并增强观察恐惧反应，独立的催产素信号通路。此外，乙醇增强自闭症模型小鼠的社会诱发恐惧反应。已经显示小鼠在观察到另一只小鼠经历恐惧条件反射时显示恐惧反应。在这里，作者表明乙醇通过前扣带皮层中的疼痛反应神经元促进社会诱发的恐惧记忆回忆。
Alcohol is a traditional social-bonding reinforcer; however, the neural mechanism underlying ethanol-driven social behaviors remains elusive. Here, we report that ethanol facilitates observational fear response. Observer mice exhibited stronger defensive immobility while observing cagemates that received repetitive foot shocks if the observer mice had experienced a brief priming foot shock. This enhancement was associated with an observation-induced recruitment of subsets of anterior cingulate cortex (ACC) neurons in the observer mouse that were responsive to its own pain. The vicariously activated ACC neurons projected their axons preferentially to the basolateral amygdala. Ethanol shifted the ACC neuronal balance toward inhibition, facilitated the preferential ACC neuronal recruitment during observation, and enhanced observational fear response, independent of an oxytocin signaling pathway. Furthermore, ethanol enhanced socially evoked fear response in autism model mice. Mice have been shown to display a fear response upon observing another mouse undergo fear conditioning. Here, the authors show that ethanol facilitates socially evoked fear memory recall, via pain-responsive neurons in the anterior cingulate cortex.
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影响因子：
4.9
作者：
Gogolla, Nadine;LeBlanc, Jocelyn J.;Quast, Kathleen B.;Sudhof, Thomas C.;Fagiolini, Michela;Hensch, Takao K.
通讯作者：
Hensch, Takao K.
DOI：
10.1038/npp.2009.45
发表时间：
2009-08
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Atsak P;Orre M;Bakker P;Cerliani L;Roozendaal B;Gazzola V;Moita M;Keysers C
通讯作者：
Keysers C
影响因子：
2.7
作者：
Aversano, M;Ciamei, A;Castellano, C
通讯作者：
Castellano, C
影响因子：
2.3
作者：
Chin, Vivien S.;Van Skike, Candice E.;Matthews, Douglas B.
通讯作者：
Matthews, Douglas B.