Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood.
Decreased heritability and emergence of novel genetic effects on pulse wave velocity from youth to young adulthood.
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DOI：
10.1038/s41598-021-88490-3
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发表时间：
2021-04-26
影响因子：
4.6
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Huang Y;Su S;Snieder H;Treiber F;Kapuku G;Wang X
通过脉搏波速度（PWV）测量的动脉硬度增加是评估心血管风险的重要参数。我们以前的纵向研究表明，颈动脉远端PWV在整个青年和青年期表现出合理的稳定性。这种稳定性可能是由随着时间的推移而一致表达的遗传因素驱动的。我们的目的是说明相对贡献的遗传和环境因素的稳定性颈动脉远端PWV从青年到青年。我们还研究了潜在的种族差异。为此目的，颈动脉远端PWV测量两次在497欧洲美国人（EA）和非洲美国人（AA）双胞胎，平均间隔时间为3年。PWV的双胞胎模型显示，遗传力随着时间的推移而下降（62-35%），非共享的环境影响变得更大。在访视1和访视2时测量的PWV的非共享环境因素之间没有相关性，随着时间的推移，共享遗传因素完全解释了表型追踪相关性（r = 0.32）。在第二次测量时，发现了新的遗传影响，占方差的很大一部分（19%）。没有种族差异的证据。总之，新的遗传效应出现在发展到青年期，并占相当大的一部分PWV的变化。随着年龄的增长，环境对PWV的影响越来越大。
Increased arterial stiffness measured by pulse wave velocity (PWV) is an important parameter in the assessment of cardiovascular risk. Our previous longitudinal study has demonstrated that carotid-distal PWV showed reasonable stability throughout youth and young adulthood. This stability might be driven by genetic factors that are expressed consistently over time. We aimed to illustrate the relative contributions of genetic and environmental factors to the stability of carotid-distal PWV from youth to young adulthood. We also examined potential ethnic differences. For this purpose, carotid-distal PWV was measured twice in 497 European American (EA) and African American (AA) twins, with an average interval time of 3 years. Twin modelling on PWV showed that heritability decreased over time (62–35%), with the nonshared environmental influences becoming larger. There was no correlation between the nonshared environmental factors on PWV measured at visit 1 and visit 2, with the phenotypic tracking correlation (r = 0.32) completely explained by shared genetic factors over time. Novel genetic influences were identified accounting for a significant part of the variance (19%) at the second measurement occasion. There was no evidence for ethnic differences. In summary, novel genetic effects appear during development into young adulthood and account for a considerable part of the variation in PWV. Environmental influences become larger with age for PWV.
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影响因子：
37.8
作者：
Mitchell GF;Hwang SJ;Vasan RS;Larson MG;Pencina MJ;Hamburg NM;Vita JA;Levy D;Benjamin EJ
通讯作者：
Benjamin EJ
影响因子：
4.9
作者：
Liang X;Su S;Hao G;Snieder H;Treiber F;Kapuku G;Wang X
通讯作者：
Wang X
影响因子：
4.9
作者：
Alvim, Rafael O.;Horimoto, Andrea R. V. R.;Pereira, Alexandre C.
通讯作者：
Pereira, Alexandre C.
DOI：
10.1161/hyp.0000000000000033
发表时间：
2015-09
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Townsend RR;Wilkinson IB;Schiffrin EL;Avolio AP;Chirinos JA;Cockcroft JR;Heffernan KS;Lakatta EG;McEniery CM;Mitchell GF;Najjar SS;Nichols WW;Urbina EM;Weber T;American Heart Association Council on Hypertension
通讯作者：
American Heart Association Council on Hypertension
影响因子：
37.8
作者：
Blacher, J;Guerin, AP;London, GM
通讯作者：
London, GM