Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.
复制标题
DOI：
10.1016/j.immuni.2009.05.014
复制
发表时间：
2009-08-21
期刊：
影响因子：
32.4
通讯作者：
Kaech, Susan M.
中科院分区：
文献类型：
--
作者：
Rutishauser, Rachel L.;Martins, Gislaine A.;Kalachikov, Sergey;Chandele, Anmol;Parish, Ian A.;Meffre, Eric;Jacob, Joshy;Calame, Kathryn;Kaech, Susan M.
在急性感染期间，一小部分效应CD8 T细胞逃避终末分化，并作为长寿记忆T细胞存活下来。我们证明，转录抑制因子Blimp - 1在淋巴细胞性脉络丛脑膜炎病毒（LCMV）感染期间促进终末分化的CD8 T细胞的形成，而Blimp - 1缺陷促进效应细胞获得记忆细胞特性。Blimp - 1的表达在终末分化的效应细胞和“效应记忆”（TEM）CD8 T细胞中优先增加，并且随着中枢记忆（TCM）细胞的发育，在感染后逐渐降低。Blimp - 1缺失的效应CD8 T细胞在效应分子表达上有所降低，但主要发育为存活更好的记忆前体细胞，并且更迅速地获得几种中枢记忆细胞的特性，包括CD62L和白细胞介素 - 2（IL - 2）的表达以及增强的增殖反应。这些结果揭示了Blimp - 1在病毒感染期间控制效应CD8 T细胞的终末分化以及抑制记忆细胞发育潜能方面的关键作用。
During acute infections, a small population of effector CD8 T cells evades terminal differentiation and survives as long-lived memory T cells. We demonstrate that the transcriptional repressor Blimp-1 enhances the formation of terminally differentiated CD8 T cells during LCMV infection, and Blimp-1 deficiency promotes the acquisition of memory cell properties by effector cells. Blimp-1 expression is preferentially increased in terminally differentiated effector and “effector memory” (TEM) CD8 T cells, and gradually decays after infection as central memory (TCM) cells develop. Blimp-1-/- effector CD8 T cells show some reduction in effector molecule expression, but primarily develop into memory precursor cells that survive better, and more rapidly acquire several TCM attributes, including CD62L and IL-2 expression and enhanced proliferative responses. These results reveal a critical role for Blimp-1 in controlling terminal differentiation and suppressing memory cell developmental potential in effector CD8 T cells during viral infection.
登录
查看更多内容
影响因子：
64.5
作者：
Kaech, SM;Hemby, S;Ahmed, R
通讯作者：
Ahmed, R
激活表型，而不是中心或效应子内存表型，可预测记忆CD8+ T细胞的回忆功效。
影响因子：
15.3
作者：
Hikono, Hirokazu;Kohlmeier, Jacob E.;Takamura, Shiki;Wittmer, Susan T.;Roberts, Alan D.;Woodland, David L.
通讯作者：
Woodland, David L.
影响因子：
30.5
作者：
Kaech, SM;Tan, JT;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
82.9
作者：
Badovinac, VP;Messingham, KAN;Harty, JT
通讯作者：
Harty, JT
影响因子：
30.5
作者：
Cannarile, Michael A.;Lind, Nicholas A.;Goldrath, Ananda W.
通讯作者：
Goldrath, Ananda W.