The association between prenatal cocaine exposure and physiological regulation at 13 months of age.
The association between prenatal cocaine exposure and physiological regulation at 13 months of age.
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13个月大时，产前可卡因暴露与生理调节之间的关联。
DOI：
10.1111/j.1469-7610.2009.02165.x
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Danielewicz S
中科院分区：
文献类型：
--
作者：
Schuetze P;Eiden RD;Danielewicz S
本研究探讨了产前可卡因暴露（PCE）和13个月大的自主神经调节之间的关联。在基线和任务期间，对156名（79名暴露和77名未暴露）婴儿进行了呼吸性窦性心律失常（RSA）的测量，这些任务旨在引发积极（PA）和消极（NA）情绪。有一个显着的抑制RSA期间的负面影响的任务，但未暴露的婴儿暴露的婴儿。母亲的抑郁或焦虑症状（MDA）没有调解这种关联。然而，性别和MDA没有缓和这种关联，暴露的男孩和暴露的婴儿，其母亲有较高水平的MDA有RSA增加的任务，旨在引起NA，而不是典型的RSA抑制模式。这些结果表明，有几个可能的途径，从PCE生理失调在婴儿后期。
This study examined the association between prenatal cocaine exposure (PCE) and autonomic regulation at 13 months of age. Measures of respiratory sinus arrhythmia (RSA) were obtained from 156 (79 exposed, and 77 nonexposed) infants during baseline and during tasks designed to elicit positive (PA) and negative affect (NA). There was a significant suppression of RSA during the negative affect task for nonexposed infants but not for exposed infants. Maternal symptoms of depression or anxiety (MDA) did not mediate this association. However, gender and MDA did moderate this association such that exposed boys and exposed infants whose mothers had higher levels of MDA had an increase in RSA during a task designed to elicit NA rather than the typical pattern of RSA suppression. These results suggest that there are several possible pathways from PCE to physiological dysregulation during late infancy.
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