Are sleep and depression independent or overlapping risk factors for cardiometabolic disease?
Are sleep and depression independent or overlapping risk factors for cardiometabolic disease?
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DOI：
10.1016/j.smrv.2010.03.001
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发表时间：
2011-02
影响因子：
10.5
通讯作者：
Matthews KA
中科院分区：
文献类型：
--
作者：
Mezick EJ;Hall M;Matthews KA
睡眠持续时间、睡眠连续性和抑郁症与心血管疾病和代谢紊乱有关。尽管睡眠和抑郁症之间的关系已经很好地建立起来，但很少有研究同时检查这些特征在心脏代谢疾病的发展中的作用。在这里，我们回顾了现有的研究，包括睡眠和抑郁症的措施与心脏代谢的结果（心血管疾病，糖尿病和代谢综合征）。总的来说，数据显示，独立于抑郁症，睡眠连续性是心血管疾病的风险因素，睡眠时间短或长是糖尿病和代谢综合征的风险因素。睡眠持续时间与心血管疾病之间的关联，以及睡眠连续性与代谢疾病之间的关联，结果更为复杂。关于抑郁症，有初步证据表明，抑郁症会增加心血管疾病的风险，与睡眠连续性无关。然而，没有足够的数据来说明抑郁症与心血管和代谢疾病之间的关系是否独立于睡眠时间。许多生物行为机制，包括炎症，下丘脑和交感神经失调，以及肥胖和健康行为，可以解释睡眠，抑郁症和心脏代谢疾病之间的关系。在总结这些机制后，我们讨论了现存文献的局限性，并提出了未来研究的方向。
Sleep duration, sleep continuity, and depression are associated with cardiovascular disease and metabolic disorders. Despite the well-established relationship between sleep and depression, few studies examine these characteristics simultaneously in the development of cardiometabolic disease. Here, we review available studies that include measures of both sleep and depression in relation to cardiometabolic outcomes (cardiovascular disease, diabetes, and the metabolic syndrome). In general, data show that independent of depression, sleep continuity is a risk factor for cardiovascular disease, and short or long sleep duration is a risk factor for diabetes and the metabolic syndrome. Results for associations between sleep duration and cardiovascular disease, and associations between sleep continuity and metabolic disease, are more mixed. Regarding depression, there is preliminary evidence that depression increases risk for cardiovascular disease, independent of sleep continuity. However, there are insufficient data to address whether relationships between depression and cardiovascular and metabolic disease are independent of sleep duration. A number of biobehavioral mechanisms, including inflammation, hypothalamic and sympathetic dysregulation, and obesity and health behaviors, may account for the relationships among sleep, depression, and cardiometabolic disease. After summarizing these mechanisms, we discuss limitations of the extant literature and suggest directions for future research.
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