Neosuberitenone, a New Sesterterpenoid Carbon Skeleton; New Suberitenones; and Bioactivity against Respiratory Syncytial Virus, from the Antarctic Sponge Suberites sp.
Neosuberitenone, a New Sesterterpenoid Carbon Skeleton; New Suberitenones; and Bioactivity against Respiratory Syncytial Virus, from the Antarctic Sponge Suberites sp.
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作者：
呼吸道合胞病毒（RSV）是一种高度传染性的人类病原体，对两岁以下儿童构成重大威胁，目前需要新的小分子治疗方法。南极海绵Suberites sp.是已知的二倍半萜来源，在核磁共振引导的分馏过程中，发现它产生了几种以前未报道的代谢物。对具有新的碳骨架（本文中称为“neosuberitane”主链）的新松潘烯酮（1）、六种松潘烯酮衍生物（2-7）、一种ansellane型萜类化合物（8）和一种高度降解的二倍半萜（9）以及先前报道的松潘烯酮A（10）和B（11）进行了表征。根据NMR、HRESIMS、旋光度和XRD数据，提出了所有分离代谢物的结构（包括绝对构型）。在一系列传染病试验中评价了代谢产物的生物活性。发现Suberitenones A、B和F（3）对RSV有活性，尽管它们与其他Suberites sp.代谢物沿着在细菌和真菌筛选中无活性。代谢产物对J774巨噬细胞或A549腺癌细胞均无细胞毒性。在其他感染因子中，辛二烯酮A、B和F对RSV的选择性是值得注意的。
Respiratory syncytial virus (RSV) is a highly contagious human pathogen that poses a significant threat to children under the age of two, and there is a current need for new small molecule treatments. The Antarctic sponge Suberites sp. is a known source of sesterterpenes, and following an NMR-guided fractionation procedure, it was found to produce several previously unreported metabolites. Neosuberitenone (1), with a new carbon scaffold herein termed the ‘neosuberitane’ backbone, six suberitenone derivatives (2–7), an ansellane-type terpenoid (8), and a highly degraded sesterterpene (9), as well as previously reported suberitenones A (10) and B (11), were characterized. The structures of all of the isolated metabolites including absolute configurations are proposed on the basis of NMR, HRESIMS, optical rotation, and XRD data. The biological activities of the metabolites were evaluated in a range of infectious disease assays. Suberitenones A, B, and F (3) were found to be active against RSV, though, along with other Suberites sp. metabolites, they were inactive in bacterial and fungal screens. None of the metabolites were cytotoxic for J774 macrophages or A549 adenocarcinoma cells. The selectivity of suberitenones A, B, and F for RSV among other infectious agents is noteworthy.
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影响因子：
6.1
作者：
Krause L;Herbst-Irmer R;Sheldrick GM;Stalke D
通讯作者：
Stalke D
影响因子：
5.1
作者：
Ma, Wai S.;Mutka, Tina;Baker, Bill J.
通讯作者：
Baker, Bill J.
针对 F 蛋白的呼吸道合胞病毒侵入抑制剂
DOI：
10.3390/v5010211
发表时间：
2013-01-16
期刊：
Viruses
影响因子：
--
作者：
Sun Z;Pan Y;Jiang S;Lu L
通讯作者：
Lu L
影响因子：
5.2
作者：
Daoust, Julie;Fontana, Angelo;Andersen, Raymond J.
通讯作者：
Andersen, Raymond J.
影响因子：
1.8
作者：
Solanki, Hiren;Angulo-Preckler, Carlos;Thomas, Olivier P.
通讯作者：
Thomas, Olivier P.