Quantitative susceptibility mapping to evaluate the early stage of Alzheimer's disease.
Quantitative susceptibility mapping to evaluate the early stage of Alzheimer's disease.
复制标题
定量敏感性映射以评估阿尔茨海默氏病的早期阶段。
DOI：
10.1016/j.nicl.2017.08.019
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Jahng GH
中科院分区：
文献类型：
--
作者：
Kim HG;Park S;Rhee HY;Lee KM;Ryu CW;Rhee SJ;Lee SY;Wang Y;Jahng GH
本研究的目的是评估认知正常（CN）老年人、遗忘性轻度认知障碍（aMCI）老年人和早期AD患者铁积累引起的易感性变化，并将其与神经元丢失引起的灰质体积（GMV）变化进行比较。参与者包括19名老年CN， 19名aMCI和19名AD受试者。计算脑内基于体素的定量敏感性图（QSM）和GMV，比较三组脑内的差异。采用单向协方差分析（ANCOVA）检验，以性别和年龄为协变量，采用基于体素（voxel）和兴趣区域（region of interest， ROI）的方法比较三组间QSM数据和gmv的差异。最后，进行受试者工作特征（ROC）曲线分析。基于体素的结果显示，与GMV相比，QSM在CN组和AD组之间显示出更多的显著差异区域。与CN组相比，aMCI组和AD组gmv降低，QSM值升高。相比GMV， QSM在楔前叶和胼胝体区域能更好地分化aMCI和CN。在铁和β淀粉样蛋白聚集区，QSM可用于区分CN组和aMCI组，这表明QSM是一种有用的早期诊断AD的辅助成像。在铁和β淀粉样蛋白积累的已知区域，易感性差异比GMV变化更敏感。与正常老年人相比，患者的QSM值升高，并且比GMV值更能区分aMCI和CN。QSM技术可作为AD早期诊断的辅助成像手段。
The objective of this study was to evaluate susceptibility changes caused by iron accumulation in cognitive normal (CN) elderly, those with amnestic mild cognitive impairment (aMCI), and those with early state AD, and to compare the findings with gray matter volume (GMV) changes caused by neuronal loss. The participants included 19 elderly CN, 19 aMCI, and 19 AD subjects. The voxel-based quantitative susceptibility map (QSM) and GMV in the brain were calculated and the differences of those insides were compared among the three groups. The differences of the QSM data and GMVs among the three groups were investigated by voxel-based and region of interest (ROI)-based comparisons using a one-way analysis of covariance (ANCOVA) test with the gender and age as covariates. Finally, a receiver-operating-characteristic (ROC) curve analysis was performed. The voxel-based results showed that QSM demonstrated more areas with significant difference between the CN and AD groups compared to GMV. GMVs were decreased, but QSM values were increased in aMCI and AD groups compared with the CN group. QSM better differentiated aMCI from CN than GMV in the precuneus and allocortex regions. In the accumulation regions of iron and amyloid β, QSM can be used to differentiate between CN and aMCI groups, indicating a useful an auxiliary imaging for early diagnosis of AD. The susceptibility difference was more sensitive than GMV change in known regions of iron and the amyloid β accumulations. QSM values were increased in patients compared with normal elderly and better differentiated aMCI from CN than GMV values. The QSM technology can be used as an auxiliary imaging for early diagnosis of AD.
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影响因子：
64.5
作者：
Duce JA;Tsatsanis A;Cater MA;James SA;Robb E;Wikhe K;Leong SL;Perez K;Johanssen T;Greenough MA;Cho HH;Galatis D;Moir RD;Masters CL;McLean C;Tanzi RE;Cappai R;Barnham KJ;Ciccotosto GD;Rogers JT;Bush AI
通讯作者：
Bush AI
影响因子：
3.7
作者：
Acosta-Cabronero J;Williams GB;Cardenas-Blanco A;Arnold RJ;Lupson V;Nestor PJ
通讯作者：
Nestor PJ
DOI：
10.1098/rsif.2014.0165
发表时间：
2014-06-06
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Everett J;Céspedes E;Shelford LR;Exley C;Collingwood JF;Dobson J;van der Laan G;Jenkins CA;Arenholz E;Telling ND
通讯作者：
Telling ND
影响因子：
3.3
作者：
Liu, Tian;Liu, Jing;Wang, Yi
通讯作者：
Wang, Yi
影响因子：
4.2
作者：
CONNOR, JR;SNYDER, BS;MUFSON, EJ
通讯作者：
MUFSON, EJ