Twenty-four-hour urinary-free cortisol in premenopausal cigarette smokers and nonsmokers.

Twenty-four-hour urinary-free cortisol in premenopausal cigarette smokers and nonsmokers.
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绝经前吸烟者和不吸烟者的二十四小时尿中游离皮质醇。

DOI:
10.1016/s0015-0282(16)53177-x
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发表时间:
1989
影响因子:
6.7
通讯作者:
Barbieri,RL
Barbieri,RL
中科院分区:
医学2区
文献类型:
--
作者:
Yeh,J;Barbieri,RL

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据报道,吸烟可引起血浆ACTH和皮质醇的急性增加,但长期吸烟对肾上腺皮质类固醇综合产生的影响尚未研究。在10名绝经前吸烟者中研究了慢性吸烟对24小时尿游离皮质醇、11-脱氧皮质醇、DHEAS和17-酮类固醇的影响,并将其结果与15名绝经前非吸烟者进行了比较。尿游离皮质醇的24小时排泄量(吸烟者为85.0+/-40.8 nmol/d,非吸烟者为81.7+/-49.7 nmol/d),11-脱氧皮质醇(吸烟者为259+/-170 nmol/d,非吸烟者为222+/-147 nmol/d),DHEAS(吸烟者为3,140 +/-2,909 nmol/d,非吸烟者为2,890 +/-1,960 nmol/d),和17-酮类固醇(吸烟者为17.4+/-8.3 mumol/d,非吸烟者为23.4+/-19.9 mumol/d)在吸烟者和非吸烟者中相似(所有P值均不显著)。我们的结论是,慢性吸烟不会导致24小时尿游离皮质醇水平异常。
Cigarette smoking has been reported to produce acute increases in plasma ACTH and cortisol, but the effect of chronic smoking on integrated adrenal steroid production has not been studied. The effects of chronic smoking on 24-hour urinary-free cortisol, 11-deoxycortisol, DHEAS, and 17-keto-steroids were studied in 10 premenopausal smokers, and their results were compared with 15 premenopausal nonsmokers. The 24-hour excretion of urinary-free cortisol (85.0+/-40.8 nmol/d in smokers versus 81.7+/-49.7 nmol/d in nonsmokers), 11-deoxycortisol (259+/-170 nmol/d in smokers versus 222+/-147 nmol/d in nonsmokers), DHEAS (3,140+/-2,909 nmol/d in smokers versus 2,890+/-1,960 nmol/d in nonsmokers), and 17-ketosteroids (17.4+/-8.3 mumol/d in smokers versus 23.4+/-19.9 mumol/d in nonsmokers) were similar in smokers and nonsmokers (all P values not significant). We conclude that chronic smoking does not result in abnormal levels of 24-hour urinary-free cortisol.
DOI: 10.1080/00032717208062119
发表时间: 1972-01-01
期刊: ANALYTICAL LETTERS
影响因子: 2
作者:
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发表时间: 1988-06-30
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DOI: --
发表时间: 1987
影响因子: 6.7
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DOI: --
发表时间: 1984
期刊: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
影响因子: --
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DOI: --
发表时间: 1984
期刊: Life Science
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