A novel brain partition highlights the modular skeleton shared by structure and function.

A novel brain partition highlights the modular skeleton shared by structure and function.
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DOI:
10.1038/srep10532
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发表时间:
2015-06-03
期刊:
影响因子:
4.6
通讯作者:
Cortes JM
Cortes JM
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Diez I;Bonifazi P;Escudero I;Mateos B;Muñoz MA;Stramaglia S;Cortes JM

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阐明健康和病理条件下大脑结构和功能之间的复杂关系是现代神经科学的关键挑战。神经影像学的最新进展有助于推进我们对这一重要问题的理解,扩散图像提供了有关结构连接(SC)的信息,功能磁共振成像揭示了静息状态功能连接(rsFC)。在这里,我们采用了一种系统的方法,依靠模块化的层次聚类,一起研究SC和rsFC数据集收集独立于健康的人类受试者。我们的新方法使我们能够找到一个由结构和功能共享的共同骨架,从中可以提取一个新的,最佳的大脑分区。我们详细描述了新兴的常见结构功能模块(SFM),并将其与常用的解剖或功能分组进行比较。我们的研究结果强调了大脑结构和静息态动力学之间的强烈对应关系,以及人类大脑的新兴连贯组织。
Elucidating the intricate relationship between brain structure and function, both in healthy and pathological conditions, is a key challenge for modern neuroscience. Recent progress in neuroimaging has helped advance our understanding of this important issue, with diffusion images providing information about structural connectivity (SC) and functional magnetic resonance imaging shedding light on resting state functional connectivity (rsFC). Here, we adopt a systems approach, relying on modular hierarchical clustering, to study together SC and rsFC datasets gathered independently from healthy human subjects. Our novel approach allows us to find a common skeleton shared by structure and function from which a new, optimal, brain partition can be extracted. We describe the emerging common structure-function modules (SFMs) in detail and compare them with commonly employed anatomical or functional parcellations. Our results underline the strong correspondence between brain structure and resting-state dynamics as well as the emerging coherent organization of the human brain.
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