Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice.
Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice.
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DOI：
10.1016/j.reprotox.2008.09.015
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发表时间：
2008-11
影响因子：
3.3
通讯作者：
Soto, Ana M.
中科院分区：
文献类型：
--
作者：
Vandenberg, Laura N.;Maffini, Maricel V.;Schaeberle, Cheryl M.;Ucci, Angelo A.;Sonnenschein, Carlos;Rubin, Beverly S.;Soto, Ana M.
关键词：
人类经常接触到双酚a (BPA)，这是一种从消费品中渗出的雌激素化合物。鉴于发育中的生物体对激素的敏感性，胎儿和婴儿的暴露是一个问题。在这里，CD-1小鼠在妊娠期和哺乳期（妊娠第8天至出生后第16天）暴露于环境相关剂量的BPA。在3个月、9个月和12-15个月大时，对暴露的后代的乳腺进行结构变化检查。bpa暴露的雌性表现出改变的乳房表型，包括肺泡芽的外观。此外，仅在bpa暴露的女性中观察到导管内增生。这些病变表现为“串珠状”导管，导管腔内存在上皮细胞，与正常导管相比，增殖指数增加。在接触其他雌激素后也观察到类似的结构。这些结果进一步证明，围产期BPA暴露可以改变成年后啮齿动物乳腺的形态。
Humans are routinely exposed to bisphenol-A (BPA), an estrogenic compound that leaches from consumer products. Given the sensitivity of the developing organism to hormones, exposure of fetuses and infants is a concern. Here, CD-1 mice were exposed to environmentally relevant doses of BPA during gestation and the lactational period (gestational day 8 through postnatal day 16). At 3, 9 and 12–15 months of age, mammary glands from exposed offspring were examined for structural changes. BPA-exposed females demonstrated altered mammary phenotypes including the appearance of alveolar buds. Additionally, intraductal hyperplasias were observed exclusively in BPA–exposed females. These lesions had the appearance of “beaded” ducts, with epithelial cells present inside the ductal lumen and increased proliferation indexes compared to normal ducts. Similar structures have also been observed following exposure to other estrogens. These results are further evidence that perinatal BPA exposure can alter the morphology of the rodent mammary gland in adulthood.
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