Direct Cardiac Reprogramming: Progress and Promise.
Direct Cardiac Reprogramming: Progress and Promise.
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DOI：
10.1155/2018/1435746
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发表时间：
2018
影响因子：
4.3
通讯作者：
Ardehali R
中科院分区：
文献类型：
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作者：
Engel JL;Ardehali R
人类成年心脏缺乏强大的内源性修复机制来完全恢复损伤后的心功能，因此，再生和修复受损心肌的能力仍然是治疗心力衰竭的首要任务。高效地产生大量能够在受损心脏内功能整合的功能性心肌细胞的能力一直是困难的。然而，在体外和体内直接将成纤维细胞转化为心肌样细胞的能力为克服这一问题提供了巨大的希望。在这篇综述中，我们描述了从心脏直接重编程研究中获得的见解和进展。我们的重点是使用关键的转录因子和致心基因，以及使用其他生物分子，如小分子、细胞因子、非编码RNA和表观遗传修饰物来提高心脏重编程的效率。最后，我们讨论了未来临床应用的更安全的重编程方法的发展。
The human adult heart lacks a robust endogenous repair mechanism to fully restore cardiac function after insult; thus, the ability to regenerate and repair the injured myocardium remains a top priority in treating heart failure. The ability to efficiently generate a large number of functioning cardiomyocytes capable of functional integration within the injured heart has been difficult. However, the ability to directly convert fibroblasts into cardiomyocyte-like cells both in vitro and in vivo offers great promise in overcoming this problem. In this review, we describe the insights and progress that have been gained from the investigation of direct cardiac reprogramming. We focus on the use of key transcription factors and cardiogenic genes as well as on the use of other biological molecules such as small molecules, cytokines, noncoding RNAs, and epigenetic modifiers to improve the efficiency of cardiac reprogramming. Finally, we discuss the development of safer reprogramming approaches for future clinical application.
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影响因子：
4.8
作者：
Dai, YS;Cserjesi, P;Molkentin, JD
通讯作者：
Molkentin, JD
影响因子：
56.9
作者：
Cao, Nan;Huang, Yu;Ding, Sheng
通讯作者：
Ding, Sheng
DOI：
10.1161/hhf.0b013e318291329a
发表时间：
2013-05
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Heidenreich PA;Albert NM;Allen LA;Bluemke DA;Butler J;Fonarow GC;Ikonomidis JS;Khavjou O;Konstam MA;Maddox TM;Nichol G;Pham M;Piña IL;Trogdon JG;American Heart Association Advocacy Coordinating Committee;Council on Arteriosclerosis, Thrombosis and Vascular Biology;Council on Cardiovascular Radiology and Intervention;Council on Clinical Cardiology;Council on Epidemiology and Prevention;Stroke Council
通讯作者：
Stroke Council
影响因子：
5
作者：
Addis RC;Ifkovits JL;Pinto F;Kellam LD;Esteso P;Rentschler S;Christoforou N;Epstein JA;Gearhart JD
通讯作者：
Gearhart JD
影响因子：
82.9
作者：
通讯作者：
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