DASH for asthma: a pilot study of the DASH diet in not-well-controlled adult asthma.
DASH for asthma: a pilot study of the DASH diet in not-well-controlled adult asthma.
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DASH 治疗哮喘：针对未得到良好控制的成人哮喘的 DASH 饮食的初步研究。
DOI：
10.1016/j.cct.2013.04.008
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发表时间：
2013-07
影响因子：
2.2
通讯作者：
Xiao L
中科院分区：
文献类型：
--
作者：
Ma J;Strub P;Lavori PW;Buist AS;Camargo CA Jr;Nadeau KC;Wilson SR;Xiao L
这项试点研究旨在为一项全面随机对照试验提供效应量置信区间、临床试验和干预可行性数据以及程序材料，该试验将确定饮食方法阻止高血压（DASH）作为标准治疗的辅助治疗对不受控制的哮喘成人的疗效。DASH饮食包括食物（例如，新鲜水果、蔬菜和坚果）和抗氧化营养素（例如，维生素A、C、E和锌）对哮喘患者有潜在的益处，但不知道整个饮食是否有益。参与者（n = 90）将随机接受单独的常规护理或与DASH干预相结合，包括前3个月内的8个小组和3个单独会议，随后至少每月一次电话咨询，持续3个月。将在3个月和6个月时进行随访评估。主要结局指标是7项Juniper哮喘控制问卷，这是一项经过验证的日间和夜间症状、活动受限、急救药物使用和1秒用力呼气量预测百分比的复合指标。我们将探讨对哮喘病理生理学重要的炎症标志物的变化（例如，呼出的一氧化氮分数）和它们介导疾病控制的干预作用的潜力。我们还将按基因型进行预先指定的亚组分析（例如，谷胱甘肽S转移酶基因的多态性）和表型（例如，特应性、肥胖症）。通过评估改善哮喘控制的饮食模式方法，这项研究可以推进证据基础，以完善关于饮食调整在哮喘管理中的作用的临床指南和公共卫生建议。
This pilot study aims to provide effect size confidence intervals, clinical trial and intervention feasibility data, and procedural materials for a full-scale randomized controlled trial that will determine the efficacy of Dietary Approaches to Stop Hypertension (DASH) as adjunct therapy to standard care for adults with uncontrolled asthma. The DASH diet encompasses foods (e.g., fresh fruit, vegetables, and nuts) and antioxidant nutrients (e.g., vitamins A, C, E, and zinc) with potential benefits for persons with asthma, but it is unknown whether the whole diet is beneficial. Participants (n = 90) will be randomized to receive usual care alone or combined with a DASH intervention consisting of 8 group and 3 individual sessions during the first 3 months, followed by at least monthly phone consultations for another 3 months. Follow-up assessments will occur at 3 and 6 months. The primary outcome measure is the 7-item Juniper Asthma Control Questionnaire, a validated composite measure of daytime and nocturnal symptoms, activity limitations, rescue medication use, and percentage predicted forced expiratory volume in 1 second. We will explore changes in inflammatory markers important to asthma pathophysiology (e.g., fractional exhaled nitric oxide) and their potential to mediate the intervention effect on disease control. We will also conduct pre-specified subgroup analyses by genotype (e.g., polymorphisms on the glutathione S transferase gene) and phenotype (e.g., atopy, obesity). By evaluating a dietary pattern approach to improving asthma control, this study could advance the evidence base for refining clinical guidelines and public health recommendations regarding the role of dietary modifications in asthma management.
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DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society
影响因子：
5
作者：
BLAIR, SN;HASKELL, WL;WOOD, PD
通讯作者：
WOOD, PD
影响因子：
4.3
作者：
Boot, J. D.;de Ridder, L.;Diamant, Z.
通讯作者：
Diamant, Z.
影响因子：
1.9
作者：
BEAL, SL
通讯作者：
BEAL, SL
影响因子：
3.1
作者：
Bahadori, Katayoun;Doyle-Waters, Mary M;FitzGerald, J Mark
通讯作者：
FitzGerald, J Mark