Cancer mortality in a population-based cohort of American Indians - The strong heart study.
Cancer mortality in a population-based cohort of American Indians - The strong heart study.
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DOI：
10.1016/j.canep.2021.101978
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发表时间：
2021-10
影响因子：
2.6
通讯作者：
Howard BV
中科院分区：
文献类型：
--
作者：
Rhoades DA;Farley J;Schwartz SM;Malloy KM;Wang W;Best LG;Zhang Y;Ali T;Yeh F;Rhoades ER;Lee E;Howard BV
美国印第安人（AI）的癌症死亡率差异很大，但与癌症死亡率相关的因素很少被评估。癌症死亡是从3516名强心研究参与者的死亡证明数据中确定的，强心研究是一项基于人群的队列研究，研究对象是亚利桑那州、俄克拉荷马州、北达科他州和南达科他州年龄在45-74岁之间的AI成年人。癌症死亡率按年龄、性别和地区计算。采用考克斯比例风险模型评估1989年基线因素与2010年癌症死亡之间的独立关联。中位随访15.3年后，癌症死亡率为6.33/1000人-年（95% CI 5.67-7.04）。北/南达科他州的男性癌症死亡率最高（8.18; 95%CI 6.46-10.23），亚利桑那州的女性癌症死亡率最低（4.57; 95%CI 2.87-6.92）。与癌症死亡率增加独立相关的因素包括年龄、目前或以前吸烟、腰围、蛋白尿、尿镉和既往癌症史。与癌症死亡率降低相关的因素包括俄克拉荷马州与达科他州相比，更高的体重指数和总胆固醇。性别与癌症死亡率无关。肺癌是癌症死亡率的主要原因（1.56/1000人-年），但亚利桑那州的参与者中没有发生肺癌死亡。未指明癌症的死亡率相对较高（0.48/100人-年; 95% CI 0.32-0.71）。尽管对个体风险因素进行了调整，但AI癌症死亡率的区域差异仍然存在。不明癌症的死亡率很高。更好地了解癌症死亡率的地区差异，以及更好地对癌症死亡进行分类，将有助于医疗保健计划解决人工智能社区的癌症问题。
Cancer mortality among American Indian (AI) people varies widely, but factors associated with cancer mortality are infrequently assessed. Cancer deaths were identified from death certificate data for 3516 participants of the Strong Heart Study, a population-based cohort study of AI adults ages 45–74 years in Arizona, Oklahoma, and North and South Dakota. Cancer mortality was calculated by age, sex and region. Cox proportional hazards model was used to assess independent associations between baseline factors in 1989 and cancer death by 2010. After a median follow-up of 15.3 years, the cancer death rate per 1000 person-years was 6.33 (95% CI 5.67–7.04). Cancer mortality was highest among men in North/South Dakota (8.18; 95% CI 6.46–10.23) and lowest among women in Arizona (4.57; 95% CI 2.87–6.92). Factors independently associated with increased cancer mortality included age, current or former smoking, waist circumference, albuminuria, urinary cadmium, and prior cancer history. Factors associated with decreased cancer mortality included Oklahoma compared to Dakota residence, higher body mass index and total cholesterol. Sex was not associated with cancer mortality. Lung cancer was the leading cause of cancer mortality overall (1.56/1000 person-years), but no lung cancer deaths occurred among Arizona participants. Mortality from unspecified cancer was relatively high (0.48/100 person-years; 95% CI 0.32–0.71). Regional variation in AI cancer mortality persisted despite adjustment for individual risk factors. Mortality from unspecified cancer was high. Better understanding of regional differences in cancer mortality, and better classification of cancer deaths, will help healthcare programs address cancer in AI communities.
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影响因子：
3.3
作者：
De Pergola G;Silvestris F
通讯作者：
Silvestris F
影响因子：
10.4
作者：
García-Esquinas E;Pollan M;Tellez-Plaza M;Francesconi KA;Goessler W;Guallar E;Umans JG;Yeh J;Best LG;Navas-Acien A
通讯作者：
Navas-Acien A
影响因子：
10.3
作者：
Albano, Jessica D.;Ward, Elizabeth;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
1.1
作者：
Haozous, Emily A.
通讯作者：
Haozous, Emily A.
DOI：
10.1158/1055-9965.epi-13-0234-t
发表时间：
2013-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
García-Esquinas E;Pollán M;Umans JG;Francesconi KA;Goessler W;Guallar E;Howard B;Farley J;Best LG;Navas-Acien A
通讯作者：
Navas-Acien A