Cadmium exposure and cancer mortality in a prospective cohort: the strong heart study.
Cadmium exposure and cancer mortality in a prospective cohort: the strong heart study.
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DOI：
10.1289/ehp.1306587
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发表时间：
2014-04
影响因子：
10.4
通讯作者：
Navas-Acien A
中科院分区：
文献类型：
--
作者：
García-Esquinas E;Pollan M;Tellez-Plaza M;Francesconi KA;Goessler W;Guallar E;Umans JG;Yeh J;Best LG;Navas-Acien A
背景：镉 (Cd) 是一种有毒金属，被国际癌症研究机构列为人类致癌物。目的：我们评估了 1989 年至 1991 年间参加强心脏研究的来自亚利桑那州、俄克拉荷马州以及北达科他州和南达科他州的美洲印第安人的尿液中测量的长期镉暴露与癌症死亡率之间的关系。方法：强心脏研究是一项前瞻性队列研究，对 3,792 名 45-74 岁的男性和女性进行了长达 20 年的随访。使用电感耦合等离子体质谱法测量基线尿镉 (U-Cd)。我们通过年度死亡率监测来评估癌症事件。结果：U-Cd 浓度中位数（五分位距）为 0.93（0.55，1.63）μg/g 肌酐。调整性别、年龄、吸烟状况、吸烟包年数和体重指数后，比较 U-Cd 第 80 个百分位数与第 20 个百分位数的调整后风险比 (HR) 为：总癌症为 1.30 (95% CI: 1.09, 1.55)，肺癌为 2.27 (95% CI: 1.58, 3.27)，肺癌为 2.40 (95% CI)。胰腺癌死亡率 CI: 1.39, 4.17)。对于所有与吸烟相关的癌症，相应的 HR 为 1.56（95% CI：1.24，1.96）。镉与肝癌、食道癌和胃癌、结肠癌和直肠癌、乳腺癌、前列腺癌、肾癌或淋巴癌和造血癌死亡率没有显着相关。根据中介分析，我们估计因吸烟导致的肺癌死亡中可归因于镉暴露的百分比为 9.0%（95% CI：2.8，21.8）。结论：低至中度镉暴露与癌症总死亡率以及肺癌和胰腺癌死亡率存在前瞻性相关。实施基于人群的预防措施来减少镉接触可能有助于减轻癌症负担。引用：García-Esquinas E、Pollan M、Tellez-Plaza M、Francesconi KA、Goessler W、Guallar E、Umans JG、Yeh J、Best LG、Navas-Acien A. 2014。前瞻性队列中的镉暴露和癌症死亡率：强心脏研究。环境健康视角 122：363–370； http://dx.doi.org/10.1289/ehp.1306587
Background: Cadmium (Cd) is a toxic metal classified as a human carcinogen by the International Agency for Research on Cancer. Objective: We evaluated the association of long-term Cd exposure, as measured in urine, with cancer mortality in American Indians from Arizona, Oklahoma, and North and South Dakota who participated in the Strong Heart Study during 1989–1991. Methods: The Strong Heart Study was a prospective cohort study of 3,792 men and women 45–74 years of age who were followed for up to 20 years. Baseline urinary Cd (U-Cd) was measured using inductively coupled plasma mass spectrometry. We assessed cancer events by annual mortality surveillance. Results: The median (interquintile range) U-Cd concentration was 0.93 (0.55, 1.63) μg/g creatinine. After adjusting for sex, age, smoking status, cigarette pack-years, and body mass index, the adjusted hazard ratios (HRs) comparing the 80th versus the 20th percentiles of U-Cd were 1.30 (95% CI: 1.09, 1.55) for total cancer, 2.27 (95% CI: 1.58, 3.27) for lung cancer, and 2.40 (95% CI: 1.39, 4.17) for pancreatic cancer mortality. For all smoking-related cancers combined, the corresponding HR was 1.56 (95% CI: 1.24, 1.96). Cd was not significantly associated with liver, esophagus and stomach, colon and rectum, breast, prostate, kidney, or lymphatic and hematopoietic cancer mortality. On the basis of mediation analysis, we estimated that the percentage of lung cancer deaths due to tobacco smoking that could be attributed to Cd exposure was 9.0% (95% CI: 2.8, 21.8). Conclusions: Low-to-moderate Cd exposure was prospectively associated with total cancer mortality and with mortality from cancers of the lung and pancreas. The implementation of population-based preventive measures to decrease Cd exposure could contribute to reducing the burden of cancer. Citation: García-Esquinas E, Pollan M, Tellez-Plaza M, Francesconi KA, Goessler W, Guallar E, Umans JG, Yeh J, Best LG, Navas-Acien A. 2014. Cadmium exposure and cancer mortality in a prospective cohort: the Strong Heart Study. Environ Health Perspect 122:363–370; http://dx.doi.org/10.1289/ehp.1306587
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影响因子：
10.4
作者：
Benbrahim-Tallaa L;Tokar EJ;Diwan BA;Dill AL;Coppin JF;Waalkes MP
通讯作者：
Waalkes MP
影响因子：
3.8
作者：
Achanzar, WE;Achanzar, KB;Waalkes, MP
通讯作者：
Waalkes, MP
影响因子：
4.9
作者：
Adams SV;Passarelli MN;Newcomb PA
通讯作者：
Newcomb PA
影响因子：
3.8
作者：
Akerstrom, Magnus;Barregard, Lars;Sallsten, Gerd
通讯作者：
Sallsten, Gerd
影响因子：
3.8
作者：
Cormet-Boyaka, Estelle;Jolivette, Kalyn;Boyaka, Prosper N.
通讯作者：
Boyaka, Prosper N.