Fasting blood glucose in a Ghanaian adult is causally affected by malaria parasite load: a mechanistic case study using convergent cross mapping.
Fasting blood glucose in a Ghanaian adult is causally affected by malaria parasite load: a mechanistic case study using convergent cross mapping.
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DOI：
10.1186/s12936-022-04076-y
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发表时间：
2022-03-18
期刊：
影响因子：
3
通讯作者：
Danquah I
中科院分区：
文献类型：
--
作者：
Abidha CA;Amoako YA;Nyamekye RK;Bedu-Addo G;Grziwotz F;Mockenhaupt FP;Telschow A;Danquah I
疟疾流行区的成年糖尿病患者可能比健康人更易感染疟原虫。在此，该研究旨在验证增加空腹血糖（FBG）促进寄生虫生长的假设，如寄生虫密度增加所反映的。在加纳农村招募了7名无糖尿病的成年人，以确定FBG和疟疾寄生虫负荷之间的关系。社会经济数据记录在基于调查的访谈中。在6周的时间内，FBG和疟原虫感染的外周血样本光度测定和聚合酶链反应（PCR）测定，分别。通过智能手机记录每日体力活动和天气数据。对于稳态葡萄糖控制和疟原虫生命周期的复杂自然系统，应用了经验动态建模。在基线时，4名男性和3名女性（中位年龄33岁;四分位距30-48）显示中位FBG为5.5（5.1-6.0 mmol/L）; 1名参与者有无症状的疟原虫感染（寄生虫密度：240/µL）。在该参与者中，连续34天的会聚交叉映射（CCM）显示FBG受寄生虫密度的因果影响（p < 0.02），而相互关系不明显（p > 0.05）。此外，日环境温度对寄生虫密度有显著影响（p < 0.01）。在这项研究中，人口生活在疟疾流行区，时间序列分析成功地试行FBG和疟原虫密度之间的关系。需要更长的观察期和更大的样本来证实这些发现并确定因果关系的方向。在线版本包含补充材料，可通过10.1186/s12936-022-04076-y获得。
Adults with diabetes mellitus (DM) in malaria-endemic areas might be more susceptible to Plasmodium infection than healthy individuals. Herein, the study was aimed at verifying the hypothesis that increased fasting blood glucose (FBG) promotes parasite growth as reflected by increased parasite density. Seven adults without DM were recruited in rural Ghana to determine the relationships between FBG and malaria parasite load. Socio-economic data were recorded in questionnaire-based interviews. Over a period of 6 weeks, FBG and Plasmodium sp. Infection were measured in peripheral blood samples photometrically and by polymerase chain reaction (PCR)-assays, respectively. Daily physical activity and weather data were documented via smartphone recording. For the complex natural systems of homeostatic glucose control and Plasmodium sp. life cycle, empirical dynamic modelling was applied. At baseline, four men and three women (median age, 33 years; interquartile range, 30–48) showed a median FBG of 5.5 (5.1–6.0 mmol/L); one participant had an asymptomatic Plasmodium sp. infection (parasite density: 240/µL). In this participant, convergent cross mapping (CCM) for 34 consecutive days, showed that FBG was causally affected by parasite density (p < 0.02), while the reciprocal relationship was not discernible (p > 0.05). Additionally, daily ambient temperature affected parasite density (p < 0.01). In this study population living in a malaria-endemic area, time series analyses were successfully piloted for the relationships between FBG and Plasmodium sp. density. Longer observation periods and larger samples are required to confirm these findings and determine the direction of causality. The online version contains supplementary material available at 10.1186/s12936-022-04076-y.
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