Transgenic models for cytokine-induced neurological disease.
Transgenic models for cytokine-induced neurological disease.
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DOI：
10.1016/j.bbadis.2009.10.004
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发表时间：
2010-10
影响因子：
6.2
通讯作者：
Pagenstecher, Axel
中科院分区：
文献类型：
--
作者：
Campbell, Iain L.;Hofer, Markus J.;Pagenstecher, Axel
关键词：
大量证据支持细胞因子是中枢神经系统 (CNS) 内病理生理过程的重要介质的观点。大量研究证明，在各种神经系统和神经精神疾病中，人类中枢神经系统中各种细胞因子的产生增加。破译完整中枢神经系统中细胞因子的作用对于我们了解这些疾病的发病机制和治疗具有重要意义。解决这一问题的一种方法已被广泛使用，即使用具有中枢神经系统靶向产生不同细胞因子的转基因小鼠。小鼠中枢神经系统中细胞因子的转基因产生不仅可以在完整大脑的局部水平上研究复杂的细胞反应，而且可以更准确地概括疾病状态下这些介质的表达。正如本综述中所讨论的，研究结果表明，这些转基因动物表现出广泛的结构和功能缺陷，这些缺陷与每种细胞因子相对特异的不同神经炎症反应的发展有关。这些细胞因子诱导的改变通常概括了在各种人类神经系统疾病中发现的改变，不仅强调了这些模型的相关性，而且还强化了细胞因子在中枢神经系统疾病中的临床病理学意义。
Considerable evidence supports the idea that cytokines are important mediators of pathophysiologic processes within the central nervous system (CNS). Numerous studies have documented the increased production of various cytokines in the human CNS in a variety of neurological and neuropsychiatric disorders. Deciphering cytokine actions in the intact CNS has important implications for our understanding of the pathogenesis and treatment of these disorders. One approach to address this problem that has been used widely employs transgenic mice with CNS-targeted production of different cytokines. Transgenic production of cytokines in the CNS of mice allows not only for the investigation of complex cellular responses at a localized level in the intact brain, but also more closely recapitulates the expression of these mediators as found in disease states. As discussed in this review, the findings show that these transgenic animals exhibit wide-ranging structural and functional deficits that are linked to the development of distinct neuroinflammatory responses which are relatively specific for each cytokine. These cytokine-induced alterations often recapitulate those found in various human neurological disorders not only underscoring the relevance of these models but also reinforcing the clinicopathogenetic significance of cytokines in diseases of the CNS.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
2.3
作者：
Ank, Nina;West, Hans;Paludan, Soren R.
通讯作者：
Paludan, Soren R.
影响因子：
2.5
作者：
BELLINGER, FP;MADAMBA, SG;SIGGINS, GR
通讯作者：
SIGGINS, GR
DOI：
10.1097/01.wcb.0000090080.64176.44
发表时间：
2003-10-01
影响因子：
6.3
作者：
Boche, D;Cunningham, C;Perry, VH
通讯作者：
Perry, VH
影响因子：
5.3
作者：
Balabanov, Roumen;Strand, Krystle;Popko, Brian
通讯作者：
Popko, Brian