Regional cerebellar volume and cognitive function from adolescence to late middle age.
Regional cerebellar volume and cognitive function from adolescence to late middle age.
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DOI：
10.1002/hbm.22690
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发表时间：
2015-03
影响因子：
4.8
通讯作者：
Mittal, Vijay A.
中科院分区：
文献类型：
--
作者：
Bernard, Jessica A.;Leopold, Daniel R.;Calhoun, Vince D.;Mittal, Vijay A.
小脑的形态和功能与多种发育障碍和健康衰老有关。虽然最近的工作已经试图在青春期，青年和老年人的这个结构的体积和年龄之间的关系的特点，有没有调查的区域小脑体积从青春期到中年后期。特别是中年，在很大程度上没有得到充分的研究，调查这一时期的生命可能对我们理解衰老特别重要。了解小脑体积的区域模式与年龄在这一部分的寿命可能提供重要的洞察健康老龄化和认知功能，以及从青春期到以后的生活病理。我们研究了区域小脑体积使用一种非常新颖的小叶分割方法，结合电池的认知任务，在一个横截面样本的123个人从12岁到65岁。我们的研究结果表明，区域小脑体积显示不同的模式，随着年龄的增长。特别是，新小脑的后部遵循二次“倒U”模式，而小脑蚓部和前小脑遵循对数模式。此外，我们量化了年龄和各种认知评估之间的关系，并发现了区域小脑体积和性能之间的关系。最后，探索性分析区域小脑体积，年龄和认知之间的关系的性别差异进行了调查。总之，这些结果为人类小脑的发育和衰老及其在整个生命周期中认知功能中的作用提供了关键见解。
Cerebellar morphology and function have been implicated in a variety of developmental disorders, and in healthy aging. Though recent work has sought to characterize the relationships between volume and age in this structure during adolescence, young, and older adulthood, there have been no investigations of regional cerebellar volume from adolescence through late middle age. Middle age in particular, has been largely understudied, and investigating this period of the lifespan may be especially important for our understanding of senescence. Understanding regional patterns of cerebellar volume with respect to age during this portion of the lifespan may provide important insight into healthy aging and cognitive function as well as pathology from adolescence into later life. We investigated regional cerebellar volume using a highly novel lobular segmentation approach in conjunction with a battery of cognitive tasks in a cross-sectional sample of 123 individuals from 12 to 65 years old. Our results indicated that regional cerebellar volumes show different patterns with respect to age. In particular, the more posterior aspect of the neocerebellum follows a quadratic “inverse-U” pattern, while the vermis and anterior cerebellum follow logarithmic patterns. In addition, we quantified the relationships between age and a variety of cognitive assessments and found relationships between regional cerebellar volumes and performance. Finally, exploratory analyses of sex differences in the relationships between regional cerebellar volume, age, and cognition were investigated. Taken together, these results provide key insights into the development and aging of the human cerebellum, and its role in cognitive function across the lifespan.
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影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
DOI：
10.1080/13803390701300524
发表时间：
2008-02-01
影响因子：
2.2
作者：
Green, Robin E. A.;Melo, Brenda;Bradbury, Cheryl
通讯作者：
Bradbury, Cheryl
影响因子：
2.9
作者：
Eckert, Mark A.;Keren, Noam I.;Harris, Kelly C.
通讯作者：
Harris, Kelly C.
影响因子：
3.7
作者：
Balsters, Joshua H.;Whelan, Christopher D.;Ramnani, Narender
通讯作者：
Ramnani, Narender
影响因子：
3.6
作者：
Benedict, RHB;Schretlen, D;Shpritz, B
通讯作者：
Shpritz, B