Anatomical and Optical Properties of Atrial Tissue: Search for a Suitable Animal Model.
Anatomical and Optical Properties of Atrial Tissue: Search for a Suitable Animal Model.
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DOI：
10.1007/s13239-017-0329-7
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发表时间：
2017-12
影响因子：
1.8
通讯作者：
Sarvazyan NA
中科院分区：
文献类型：
--
作者：
Muselimyan N;Jishi MA;Asfour H;Swift L;Sarvazyan NA
本研究的目的是评估普通动物模型心房组织的结构和光学特性，并将其与人类心房进行比较。我们的目标是以一种有助于开发更好的消融工具和/或观察心房病变的新方法的形式来进行这项研究。将临床相关年龄组的人心房组织与通常用于研究目的的大型动物模型的心房组织进行比较和对比。这些动物包括猪、羊、狗和牛。所提供的数据包括可用于消融的平滑心房表面的面积测量以及对五种不同种类的胶原蛋白和肌肉厚度的估计。我们还描述了量化胶原蛋白存在和心房壁总厚度的方法。所提供的信息能够将心房病变定位到与临床相关的心房壁厚度和宏观结构的位置，最终帮助研究人员开发更好的消融和成像工具。它还强调了胶原蛋白厚度对光学测量和病变可视化的影响。
The purpose of this study was to evaluate structural and optical properties of atrial tissue from common animal models and to compare it with human atria. We aimed to do this in a format that will be useful for development of better ablation tools and/or new means for visualizing atrial lesions. Human atrial tissue from clinically relevant age group was compared and contrasted with atrial tissue of large animal models commonly available for research purposes. These included pigs, sheep, dogs and cows. The presented data include area measurements of smooth atrial surface available for ablation and estimates of thickness of collagen and muscle for five different species. We also described methods to quantify presence of collagen and overall thickness of atrial wall. Provided information enables placement of atrial lesions to locations with clinically relevant atrial wall thickness and macroscopic structure ultimately helping investigators to develop better ablation and imaging tools. It also highlights the impact of collagen thickness on optical measurements and lesion visualization.
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DOI：
10.1016/j.cjca.2013.07.672
发表时间：
2013-10
期刊：
The Canadian journal of cardiology
影响因子：
--
作者：
Baykaner T;Clopton P;Lalani GG;Schricker AA;Krummen DE;Narayan SM;CONFIRM Investigators
通讯作者：
CONFIRM Investigators
影响因子：
3.7
作者：
Muselimyan N;Swift LM;Asfour H;Chahbazian T;Mazhari R;Mercader MA;Sarvazyan NA
通讯作者：
Sarvazyan NA
影响因子：
2.8
作者：
Chen, Han-Yang;Gore, Joel M.;Goldberg, Robert J.
通讯作者：
Goldberg, Robert J.
影响因子：
6.1
作者：
Defaye, Pascal;Kane, Adama;Jacon, Peggy
通讯作者：
Jacon, Peggy
影响因子：
2.8
作者：
Gil DA;Swift LM;Asfour H;Muselimyan N;Mercader MA;Sarvazyan NA
通讯作者：
Sarvazyan NA