Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals.
Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals.
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DOI：
10.18632/aging.101557
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发表时间：
2018-09-16
期刊：
影响因子：
--
通讯作者：
Higami Y
中科院分区：
文献类型：
--
作者：
Hoshino S;Kobayashi M;Higami Y
热量限制（CR）延长寿命和抑制各种病理生理变化已被广泛接受。CR抑制生长激素/胰岛素样生长因子信号传导和雷帕霉素复合物1活性的机制靶点，激活沉默调节蛋白并增强线粒体氧化还原调节，但确切机制仍在争论中。本文从Holliday（1989）提出的适应性反应假说出发，结合分子生物学和遗传学技术的最新进展，对CR的发生机制进行了探讨。然后，我们解释了CR的有益作用，根据它们是否在进食或禁食条件下起作用而分类。
It is widely accepted that caloric restriction (CR) extends lifespan and suppresses various pathophysiological changes. CR suppresses growth hormone/insulin-like growth factor signaling and mechanistic target of rapamycin complex 1 activity, activates sirtuin and enhances mitochondrial redox regulation, but the exact mechanisms are still under debate. In this review, we discuss the mechanisms of CR using evidence from studies of animals that were genetically modified according to recent advances in molecular and genetic technologies, from the viewpoint of the adaptive response hypothesis proposed by Holliday (1989). We then explain the beneficial actions of CR, classified according to whether they operate under feeding or fasting conditions.
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影响因子：
4.6
作者：
Chiba T;Tamashiro Y;Park D;Kusudo T;Fujie R;Komatsu T;Kim SE;Park S;Hayashi H;Mori R;Yamashita H;Chung HY;Shimokawa I
通讯作者：
Shimokawa I
啮齿动物的卡路里限制：要考虑的警告。
影响因子：
13.1
作者：
Ingram DK;de Cabo R
通讯作者：
de Cabo R
DOI：
10.1007/s11357-000-0002-0
发表时间：
2000-01-01
期刊：
JOURNAL OF THE AMERICAN AGING ASSOCIATION
影响因子：
--
作者：
Mattison, JA;Wright, C;Bartke, A
通讯作者：
Bartke, A
影响因子：
21.3
作者：
Komatsu, Masaaki;Kurokawa, Hirofumi;Yamamoto, Masayuki
通讯作者：
Yamamoto, Masayuki
影响因子：
11.4
作者：
Giblin, William;Skinner, Mary E.;Lombard, David B.
通讯作者：
Lombard, David B.