Community behavior and amyloid-associated phenotypes among a panel of uropathogenic E. coli.
Community behavior and amyloid-associated phenotypes among a panel of uropathogenic E. coli.
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一组尿路致病性大肠杆菌中的群落行为和淀粉样蛋白相关表型。
DOI：
10.1016/j.bbrc.2013.11.026
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发表时间：
2014
影响因子：
3.1
通讯作者：
Cegelski,Lynette
中科院分区：
文献类型：
--
作者：
Lim,JiYoun;Pinkner,JeromeS;Cegelski,Lynette
尿路致病性大肠杆菌（UPEC）是尿路感染的主要病原体，通过基因和分子级联反应在尿路定植。破坏毒力因子和细菌生物膜的组装和/或功能已经成为开发预防和治疗尿路感染的新治疗策略的有吸引力的目标，特别是在人类病原体中抗生素耐药性增加的时代。UPEC在其遗传和分子表型方面差异很大，需要更多的数据来了解区分分离株的毒性或强或弱以及更强大的生物膜形成者或较差的生物膜形成者的特征。卷曲是由大肠杆菌产生的细胞外功能性淀粉样纤维。在尿路感染（UTI）期间，大肠杆菌参与致病并影响宿主反应。我们已经检查了curli和curli相关表型的产生，包括在一组特定的人类临床UPEC中的生物膜形成，该UPEC已经在UTI小鼠模型中进行了广泛的研究。运动性、卷曲产生和附着于塑料的卷曲相关生物膜形成是最普遍的行为，为大多数临床分离株所共有。我们讨论了这些结果的背景下，先前报道的行为和表型的这些菌株在小鼠膀胱炎模型体内。
UropathogenicEscherichia coli(UPEC) are the major causative agents of urinary tract infection and engage in a coordinated genetic and molecular cascade to colonize the urinary tract. Disrupting the assembly and/or function of virulence factors and bacterial biofilms has emerged as an attractive target for the development of new therapeutic strategies to prevent and treat urinary tract infection, particularly in the era of increasing antibiotic resistance among human pathogens. UPEC vary widely in their genetic and molecular phenotypes and more data are needed to understand the features that distinguish isolates as more or less virulent and as more robust biofilm formers or poor biofilm formers. Curli are extracellular functional amyloid fibers produced byE. colithat contribute to pathogenesis and influence the host response during urinary tract infection (UTI). We have examined the production of curli and curli-associated phenotypes including biofilm formation among a specific panel of human clinical UPEC that has been studied extensively in the mouse model of UTI. Motility, curli production, and curli-associated biofilm formation attached to plastic were the most prevalent behaviors, shared by most clinical isolates. We discuss these results in the context on the previously reported behavior and phenotypes of these isolates in the murine cystitis modelin vivo.
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影响因子：
14.8
作者：
Cegelski, Lynette;Pinkner, Jerome S.;Hammer, Neal D.;Cusumano, Corinne K.;Hung, Chia S.;Chorell, Erik;Aberg, Veronica;Walker, Jennifer N.;Seed, Patrick C.;Almqvist, Fredrik;Chapman, Matthew R.;Hultgren, Scott J.
通讯作者：
Hultgren, Scott J.
DOI：
10.1039/c2cc37792f
发表时间：
2013-05-14
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
McCrate OA;Zhou X;Cegelski L
通讯作者：
Cegelski L
产肠毒素大肠杆菌的 Curli 表达。
DOI：
--
发表时间：
2005
期刊：
Folia Microbiologica (Prague)
影响因子：
--
作者：
E. Szabó;A. Skedsmo;Á. Sonnevend;K. al;L. Emődy;A. Usmani;T. Pál
通讯作者：
T. Pál
DOI：
10.1021/la304710k
发表时间：
2013-01-22
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Wu C;Lim JY;Fuller GG;Cegelski L
通讯作者：
Cegelski L
人尿道上皮细胞的鞘糖脂作为粘附大肠杆菌的可能受体。
DOI：
--
发表时间：
1980
期刊：
Scandinavian Journal of Infectious Diseases. Supplementum
影响因子：
--
作者：
C. Edén;H. Leffler
通讯作者：
H. Leffler