Intramuscular Fat Accumulation and Associations With Body Composition, Strength, and Physical Functioning in Patients With Rheumatoid Arthritis.
Intramuscular Fat Accumulation and Associations With Body Composition, Strength, and Physical Functioning in Patients With Rheumatoid Arthritis.
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DOI：
10.1002/acr.23550
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发表时间：
2018-12
影响因子：
4.7
通讯作者：
Leonard MB
中科院分区：
文献类型：
--
作者：
Baker JF;Mostoufi-Moab S;Long J;Zemel B;Ibrahim S;Taratuta E;Leonard MB
风湿性关节炎（RA）与不良的身体组成特征和由于肌内脂肪积累导致的低肌肉密度有关。本研究评估了RA患者和参照组的肌肉密度、身体成分、肌肉力量和身体功能之间的关系。年龄18-70岁的RA患者和健康对照参与者完成全身DXA和外周定量CT（pQCT），以量化非典型瘦体重（ALMI，kg/m2）和脂肪质量指数（FMI，kg/m2）、内脏脂肪面积和肌肉密度。测力法用于测量手握力和膝盖和小腿的肌肉力量（英尺磅）。残疾和身体功能的测量与健康评估问卷（HAQ）和简短的物理性能电池（SPPB）。线性回归分析评估了与RA相关的差异以及肌肉密度、力量和功能之间的关联。该研究包括103名RA患者（51名男性）和428名健康参与者。低肌肉密度与疾病活动性、CRP和白细胞介素-6、总脂肪和内脏脂肪量、ALMI Z评分、缺乏运动和长期使用糖皮质激素（> 1年）相关。与具有类似低ALMI的参考参与者相比，具有低ALMI Z评分的患者具有较低的肌肉密度Z评分。在调整ALMI和FMI Z评分后，低肌肉密度与较低的肌肉力量、较高的HAQ和较低的SPPB独立相关。在RA患者中观察到的低肌肉密度与低肌肉质量、过度肥胖、力量差和更严重的残疾相关。解决肌肉质量差的干预措施可能会影响重要的功能结果。
Rheumatoid arthritis (RA) is associated with adverse body composition profiles, and low muscle density due to accumulation of intramuscular fat. This study assessed associations between muscle density, body composition, muscle strength, and physical functioning in patients with RA and a reference group. Patients with RA, ages 18–70 years, and healthy control participants completed whole-body DXA and peripheral quantitative CT (pQCT) to quantify appendicular lean mass (ALMI, kg/m2) and fat mass indices (FMI, kg/m2), visceral fat area, and muscle density. Dynamometry was used to measure hand-grip strength and muscle strength at the knee and lower leg (ft-lbs). Disability and physical functioning were measured with the Health Assessment Questionnaire (HAQ) and the Short Physical Performance Battery (SPPB). Linear regression analyses assessed differences related to RA and associations between muscle density, strength, and function. The study consisted of 103 RA patients (51 men) and 428 healthy participants. Low muscle density was associated with greater disease activity, CRP, and Interleukin-6, greater total and visceral fat, lower ALMI Z-Scores, physical inactivity, and long-term use of glucocorticoids (>1yr). Patients with low ALMI Z-Scores had lower muscle density Z-Score compared to reference participants with similarly low ALMI. Low muscle density was independently associated with lower muscle strength, higher HAQ, and lower SPPB after adjusting for ALMI and FMI Z-Scores. Low muscle density observed among patients with RA is observed in association with low muscle mass, excess adiposity, poor strength, and greater disability. Interventions to address poor muscle quality could potentially affect important functional outcomes.
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DOI：
10.1359/jbmr.090807
发表时间：
2010-03
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Lang T;Cauley JA;Tylavsky F;Bauer D;Cummings S;Harris TB;Health ABC Study
通讯作者：
Health ABC Study
影响因子：
4.7
作者：
Baker JF;Von Feldt J;Mostoufi-Moab S;Noaiseh G;Taratuta E;Kim W;Leonard MB
通讯作者：
Leonard MB
DOI：
10.1093/gerona/glv185
发表时间：
2016-06-01
影响因子：
5.1
作者：
Anderson, Dennis E.;Quinn, Emily;Kiel, Douglas P.
通讯作者：
Kiel, Douglas P.
影响因子：
7.1
作者：
KELLEY, DE;SLASKY, BS;JANOSKY, J
通讯作者：
JANOSKY, J
影响因子：
5
作者：
Bild, DE;Bluemke, DA;Tracy, RP
通讯作者：
Tracy, RP