Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study.
Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study.
复制标题
DOI：
10.1359/jbmr.090807
复制
发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Health ABC Study
中科院分区：
文献类型：
--
作者：
Lang T;Cauley JA;Tylavsky F;Bauer D;Cummings S;Harris TB;Health ABC Study
肌肉脂肪浸润，肌肉脂肪变性，随着年龄的增长而增加，导致肌肉力量和功能下降，跌倒风险增加。然而，尚不清楚肌肉脂肪浸润增加是否易导致髋部骨折。我们测量了大腿中部肌肉束内瘦肉组织的平均亨氏单位（HU（大腿肌肉HU，肌内脂肪的指标），其横截面积（CSA，肌肉质量的测量），髋关节的骨矿物质密度（BMD）和全身脂肪百分比，等速腿伸肌力量，和短期身体机能成套测验（SPPB），在2941名年龄在70至79岁的白色和黑人妇女和男子中进行。在6.6年的随访中，对63例髋部骨折进行了确认。比例风险回归分析用于评估髋部骨折的相对风险（RR），包括大腿肌肉衰减、CSA、肌力和髋部骨折的身体功能。在根据年龄、种族、性别、体重指数和脂肪百分比调整的模型中，大腿肌肉HU降低导致髋部骨折风险增加[RR/SD = 1.58; 95%置信区间（CI）1.10-1.99]，进一步调整BMD后，这种相关性仍然显著。在通过CSA、肌肉力量和SPPB评分额外校正的模型中，大腿肌肉HU降低，但其他肌肉参数均未继续与髋部骨折风险增加相关（RR/SD = 1.42; 95% CI 1.03-1.97）。大腿肌肉HU降低（肌肉脂肪浸润的测量）与髋部骨折风险增加相关，并且似乎解释了肌肉力量、体能和肌肉质量降低与髋部骨折风险之间的关联。该特征捕获肌肉组织的物理特征，其可能在髋部骨折病因学中具有重要性。© 2010美国骨与矿物质研究学会
Fatty infiltration of muscle, myosteatosis, increases with age and results in reduced muscle strength and function and increased fall risk. However, it is unknown if increased fatty infiltration of muscle predisposes to hip fracture. We measured the mean Hounsfield unit (HU) of the lean tissue within the midthigh muscle bundle (thigh muscle HU, an indicator of intramuscular fat), its cross-sectional area (CSA, a measure of muscle mass) by computed tomography (CT), bone mineral density (BMD) of the hip and total-body percent fat by dual X-ray absorptiometry (DXA), isokinetic leg extensor strength, and the Short Physical Performance Battery (SPPB) in 2941 white and black women and men aged 70 to 79 years. Sixty-three hip fractures were validated during 6.6 years of follow-up. Proportional hazards regression analysis was used to assess the relative risk (RR) of hip fracture across variations in thigh muscle attenuation, CSA, muscle strength, and physical function for hip fracture. In models adjusted by age, race, gender, body mass index, and percentage fat, decreased thigh muscle HU resulted in increased risk of hip fracture [RR/SD = 1.58; 95% confidence interval (CI) 1.10–1.99], an association that continued to be significant after further adjustment for BMD. In models additionally adjusted by CSA, muscle strength, and SPPB score, decreased thigh muscle HU but none of the other muscle parameters continued to be associated with an increased risk of hip fracture (RR/SD = 1.42; 95% CI 1.03–1.97). Decreased thigh muscle HU, a measure of fatty infiltration of muscle, is associated with increased risk of hip fracture and appears to account for the association between reduced muscle strength, physical performance, and muscle mass and risk of hip fracture. This characteristic captures a physical characteristic of muscle tissue that may have importance in hip fracture etiology. © 2010 American Society for Bone and Mineral Research
登录
查看更多内容
影响因子：
3.3
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
通讯作者：
Newman, AB
DOI：
10.1111/j.1532-5415.2000.tb04694.x
发表时间：
2000-04-01
影响因子：
6.3
作者：
Visser, M;Deeg, DJH;Bouter, LM
通讯作者：
Bouter, LM
DOI：
10.1139/h05-101
发表时间：
2005-02-01
期刊：
CANADIAN JOURNAL OF APPLIED PHYSIOLOGY-REVUE CANADIENNE DE PHYSIOLOGIE APPLIQUEE
影响因子：
--
作者：
Ducher, G;Jaffré, C;Courteix, D
通讯作者：
Courteix, D
影响因子：
4
作者：
Sennerby, U.;Farahmand, B.;Michaelsson, K.
通讯作者：
Michaelsson, K.
影响因子：
4.1
作者：
Lang, T.;Koyama, A.;Cheng, X.
通讯作者：
Cheng, X.