Ion channel molecular complexes in vascular smooth muscle.
Ion channel molecular complexes in vascular smooth muscle.
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DOI:
10.3389/fphys.2022.999369
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发表时间:
2022
影响因子:
4
通讯作者:
中科院分区:
文献类型:
--
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Ion channels that influence membrane potential and intracellular calcium concentration control vascular smooth muscle excitability. Voltage-gated calcium channels (VGCC), transient receptor potential (TRP) channels, voltage (KV), and Ca2+-activated K+ (BK) channels are key regulators of vascular smooth muscle excitability and contractility. These channels are regulated by various signaling cues, including protein kinases and phosphatases. The effects of these ubiquitous signaling molecules often depend on the formation of macromolecular complexes that provide a platform for targeting and compartmentalizing signaling events to specific substrates. This manuscript summarizes our current understanding of specific molecular complexes involving VGCC, TRP, and KV and BK channels and their contribution to regulating vascular physiology.
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DOI:
10.1113/jp272262
发表时间:
2016-10-01
期刊:
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影响因子:
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作者:
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通讯作者:
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影响因子:
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DOI:
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发表时间:
2001-09-01
影响因子:
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作者:
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通讯作者:
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影响因子:
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