High acceptability of HIV pre-exposure prophylaxis but challenges in adherence and use: qualitative insights from a phase I trial of intermittent and daily PrEP in at-risk populations in Kenya.
High acceptability of HIV pre-exposure prophylaxis but challenges in adherence and use: qualitative insights from a phase I trial of intermittent and daily PrEP in at-risk populations in Kenya.
复制标题
DOI：
10.1007/s10461-012-0317-8
复制
发表时间：
2013-07
影响因子：
4.4
通讯作者：
Sanders, Eduard Joachim
中科院分区：
文献类型：
--
作者：
Van der Elst, Elisabeth Maria;Mbogua, Judie;Operario, Don;Mutua, Gaudensia;Kuo, Caroline;Mugo, Peter;Kanungi, Jennifer;Singh, Sagri;Haberer, Jessica;Priddy, Frances;Sanders, Eduard Joachim
本文采用定性方法，探讨经验的男性与男性发生性关系和女性性工作者在内罗毕和姆特瓦帕，肯尼亚，谁使用口服暴露前预防（PrEP）预防艾滋病毒的一部分，为期四个月的试验的安全性，可接受性和坚持。参加随机，安慰剂对照，盲法试验的72名志愿者中有51名在完成试验后进行了定性评估，该试验比较了每日和间歇剂量的PrEP。分析确定了三个主题：（i）PrEP的可接受性很高，即在研究早期经历了副作用，但随着时间的推移而减少，然而药丸的特性可以改善舒适度和使用;（ii）由于被认为是HIV阳性而造成的耻辱，谣言和关系困难等社会影响普遍存在;（iii）依从性受到日常生活复杂性的挑战，特别是性交后给药依从性受到性交前后饮酒，移动的人群，和性交易这些主题在给药方案和性别之间产生了共鸣，虽然大多数参与者倾向于间歇性给药方案，但间歇性组的参与者在坚持性交后剂量方面遇到了特殊的挑战。解决这些问题的文化适当和一致的咨询可能是PrEP有效性的关键。
This paper used qualitative methods to explore experiences of men who have sex with men and female sex workers in Nairobi and Mtwapa, Kenya, who used oral preexposure prophylaxis (PrEP) for HIV prevention as part of a four-month trial of safety, acceptability and adherence. Fifty-one of 72 volunteers who took part in a randomized, placebo-controlled, blinded trial that compared daily and intermittent dosage of PrEP underwent qualitative assessments after completing the trial. Analyses identified three themes: (i) acceptability of PrEP was high, i.e. side effects were experienced early in the study but diminished over time, however characteristics of pills could improve comfort and use; (ii) social impacts such as stigma, rumors, and relationship difficulties due to being perceived as HIV positive were prevalent; (iii) adherence was challenged by complexities of daily life, in particular post-coital dosing adherence suffered from alcohol use around time of sex, mobile populations, and transactional sex work. These themes resonated across dosing regimens and gender, and while most participants favored the intermittent dosing schedule, those in the intermittent group noted particular challenges in adhering to the post-coital dose. Culturally appropriate and consistent counseling addressing these issues may be critical for PrEP effectiveness.
登录
查看更多内容
DOI：
10.1097/qai.0b013e3181e19a54
发表时间：
2010-08
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Golub SA;Kowalczyk W;Weinberger CL;Parsons JT
通讯作者：
Parsons JT
包装准备以防止艾滋病毒：一个综合框架，以计划在临床实践中实施暴露前预防。
DOI：
10.1097/qai.0b013e3181e8efe4
发表时间：
2010-09
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Underhill K;Operario D;Skeer M;Mimiaga M;Mayer K
通讯作者：
Mayer K
DOI：
10.1097/qai.0b013e31818d5a27
发表时间：
2009-01-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Mimiaga MJ;Case P;Johnson CV;Safren SA;Mayer KH
通讯作者：
Mayer KH
影响因子：
15.8
作者：
Denton PW;Estes JD;Sun Z;Othieno FA;Wei BL;Wege AK;Powell DA;Payne D;Haase AT;Garcia JV
通讯作者：
Garcia JV
影响因子：
168.9
作者：
Paxton, Lynn A.;Hope, Tony;Jaffe, Harold W.
通讯作者：
Jaffe, Harold W.