The circadian clock and asthma
The circadian clock and asthma
复制标题
生物钟和哮喘
作者：
H. Durrington;S. Farrow;A. Loudon;D. Ray
哮喘的特征是症状在夜间恶化，特别是在清晨。哮喘患者的夜间症状很常见，是治疗升级的重要指标。大量研究表明，咳嗽和呼吸困难的夜间症状伴随着气道炎症和生理变量的昼夜变化，包括气流限制和气道高反应性。由所谓的“时钟”基因控制的支持昼夜节律变化的分子装置最近已经被表征。生物钟基因控制着昼夜节律，既控制着大脑视交叉上核的中枢，也控制着身体每个器官的外周。在这里，我们将讨论时钟基因如何调节昼夜节律。我们将特别关注外周肺生物钟和外周免疫生物钟，并讨论它们如何与哮喘的发病机制和治疗相关。
It is characteristic of asthma that symptoms worsen overnight, particularly in the early hours of the morning. Nocturnal symptoms in asthma are common and are an important indicator for escalation of treatment. An extensive body of research has demonstrated that nocturnal symptoms of cough and dyspnea are accompanied by circadian variations in airway inflammation and physiologic variables, including airflow limitation and airways hyper-responsiveness. The molecular apparatus that underpins circadian variations, controlled by so called ‘clock’ genes, has recently been characterised. Clock genes control circadian rhythms both centrally, in the suprachiasmatic nucleus of the brain and peripherally, within every organ of the body. Here, we will discuss how clock genes regulate circadian rhythms. We will focus particularly on the peripheral lung clock and the peripheral immune clock and discuss how these might relate to both the pathogenesis and treatment of asthma.
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