Development of fetal brain renin-angiotensin system and hypertension programmed in fetal origins.
Development of fetal brain renin-angiotensin system and hypertension programmed in fetal origins.
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DOI：
10.1016/j.pneurobio.2008.12.001
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发表时间：
2009-04
影响因子：
6.7
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Mao C;Shi L;Xu F;Zhang L;Xu Z
自20世纪80年代提出成人疾病起源于胎儿的概念以来，肾素-血管紧张素系统（RAS）在正常和异常模式中的发展引起了人们的关注。最近的研究表明，胎儿RAS在产前和产后发育的重要性。本文综述了胎儿脑RAS的功能发育，以及子宫内局部脑RAS成分的个体发生。中枢RAS在控制胎儿心血管反应、体液平衡和神经内分泌调节中起重要作用。最近取得的进展表明，环境损害导致的胎儿RAS发育改变可能会影响晚年高血压的“编程”。鉴于中枢RAS与外周RAS在心血管调节中具有同等重要性，研究胎儿脑RAS在正常和异常模式下的发育可能有助于阐明胎儿起源的成人心血管疾病的“编程”机制。
Since the concept of fetal origins of adult diseases was introduced in 1980s, the development of the renin–angiotensin system (RAS) in normal and abnormal patterns has attracted attention. Recent studies have shown the importance of the fetal RAS in both prenatal and postnatal development. This review focuses on the functional development of the fetal brain RAS, and ontogeny of local brain RAS components in utero. The central RAS plays an important role in the control of fetal cardiovascular responses, body fluid balance, and neuroendocrine regulation. Recent progress has been made in demonstrating that altered fetal RAS development as a consequence of environmental insults may impact on “programming” of hypertension later in life. Given that the central RAS is of equal importance to the peripheral RAS in cardiovascular regulation, studies on the fetal brain RAS development in normal and abnormal patterns could shed light on “programming” mechanisms of adult cardiovascular diseases in fetal origins.
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影响因子：
9.8
作者：
El-Haddad, MA;Chao, CR;Ross, MG
通讯作者：
Ross, MG
DOI：
10.1016/s0169-328x(97)00339-2
发表时间：
1998-03-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Baltatu, O;Lippoldt, A;Bader, M
通讯作者：
Bader, M
影响因子：
4.1
作者：
ALESSIO, MLM;LEGER, CL;KORDON, C
通讯作者：
KORDON, C
影响因子：
8.3
作者：
FELIX, D;KHOSLA, MC;FERRARIO, CM
通讯作者：
FERRARIO, CM
影响因子：
8.3
作者：
Dodic, M;Abouantoun, T;Moritz, KM
通讯作者：
Moritz, KM