Allostatic load, unhealthy behaviors, and depressive symptoms in the Hispanic Community Health Study/Study of Latinos.
Allostatic load, unhealthy behaviors, and depressive symptoms in the Hispanic Community Health Study/Study of Latinos.
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DOI：
10.1016/j.ssmph.2021.100917
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Pérez-Stable EJ
中科院分区：
文献类型：
--
作者：
Rodriquez EJ;Coreas SI;Gallo LC;Isasi CR;Salazar CR;Bandiera FC;Suglia SF;Perreira KM;Hernandez R;Penedo F;Talavera GA;Daviglus ML;Pérez-Stable EJ
环境负担能力模型（EAM）提出，慢性压力对抑郁症的影响受到不健康行为和种族/民族的调节。在美国的西班牙裔/拉丁裔的独特的社会结构和背景可能会影响这种关系。这项研究评估了不健康行为是否削弱了西班牙裔社区健康研究/拉丁裔参与者研究中非稳态负荷（慢性压力的衡量标准）与未来抑郁症状升高之间的关系。分析了来自11，623名参与者的纵向数据（2008-2011和2014-2017）。在访视1时，暴露为非稳态负荷，这是使用临床相关临界点分类的12种已确立生物标志物的指数。在访视2时，抑郁症状升高可操作为CES-D 10评分≥10（30分）。将访视1时吸烟、过量/酗酒、久坐行为和饮食质量差的不健康行为指数各1分作为效应修正因子进行检查。多变量逻辑回归，在总体样本中，特别是在墨西哥人中，并根据访视1时的人口统计学特征和抑郁症状升高进行调整，用于模拟非稳态负荷、不健康行为指数（范围：0-4）及其与访视2时抑郁症状升高相关的相互作用。总体而言，更大的非稳态负荷与至少6年后抑郁症状升高的几率更高相关（aOR = 1.06，95%CI = 1.01，1.10）。总体而言，与不健康行为指数= 0的个体相比，具有更大的非稳态负荷和不健康行为指数= 1的个体在随访时抑郁症状升高的几率较低（aβ =-0.065，95%CI =-0.12，-0.007）。慢性压力和抑郁症之间的关系在从事不健康行为的西班牙裔/拉丁美洲人中部分缓和，这可能降低了他们在更多的慢性压力下抑郁症状升高的风险。不健康的行为可能会减少慢性压力对抑郁症状的影响。研究了非稳态负荷、不健康行为和抑郁症状的升高。非稳态负荷与抑郁症状升高之间的纵向关联。一种不健康的行为与拉丁美洲人更大的非稳态负荷相互作用。调查结果部分支持拉丁美洲人之间的环境负担能力模型。
The Environmental Affordances Model (EAM) proposes that the effects of chronic stress on depression are moderated by unhealthy behaviors and race/ethnicity. The unique social structures and contexts of Hispanics/Latinos in the U.S. may influence such relationships. This study evaluated whether unhealthy behaviors weakened the relationship between allostatic load, a measure of chronic stress, and future elevated depressive symptoms among Hispanic Community Health Study/Study of Latinos participants. Longitudinal data (2008–2011 and 2014–2017) from 11,623 participants were analyzed. The exposure was allostatic load, an index of twelve established biomarkers categorized using clinically relevant cut points, at Visit 1. Elevated depressive symptoms were operationalized as a score of ≥10 (out of 30) on the CES-D 10 at Visit 2. An index of unhealthy behaviors, with one point each for cigarette smoking, excessive/binge drinking, sedentary behavior, and poor diet quality at Visit 1, was examined as an effect modifier. Multivariable logistic regression, in the overall sample and among Mexicans specifically and adjusted for demographic characteristics and elevated depressive symptoms at Visit 1, was used to model allostatic load, unhealthy behavior index (range: 0–4), and their interaction in relation to elevated depressive symptoms at Visit 2. Overall, greater allostatic load was associated with higher odds of elevated depressive symptoms after at least 6 years (aOR = 1.06, 95% CI = 1.01, 1.10). Overall, individuals with greater allostatic load and an unhealthy behavior index = 1, compared to those with an unhealthy behavior index = 0, had lower odds of elevated depressive symptoms at follow-up (aβ = −0.065, 95% CI = −0.12, −0.007). The relationship between chronic stress and depression was partially moderated among Hispanics/Latinos who engaged in unhealthy behavior, which may have reduced their risk of elevated depressive symptoms given more chronic stress. Unhealthy behaviors may reduce the effect of chronic stress on depressive symptoms. Allostatic load, unhealthy behaviors, and elevated depressive symptoms were studied. Longitudinal association between allostatic load and elevated depressive symptoms. One unhealthy behavior interacted with greater allostatic load among Latinos. Findings partially support the Environmental Affordances Model among Latinos.
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影响因子：
4.9
作者：
Estrada-Martinez, Lorena M.;Caldwell, Cleopatra H.;Bauermeister, Jose A.;Zimmerman, Marc A.
通讯作者：
Zimmerman, Marc A.
影响因子：
5.6
作者：
Lavange, Lisa M.;Kalsbeek, William D.;Sorlie, Paul D.;Aviles-Santa, Larissa M.;Kaplan, Robert C.;Barnhart, Janice;Liu, Kiang;Giachello, Aida;Lee, David J.;Ryan, John;Criqui, Michael H.;Elder, John P.
通讯作者：
Elder, John P.
影响因子：
12.7
作者：
Jackson JS;Knight KM;Rafferty JA
通讯作者：
Rafferty JA
影响因子：
5.4
作者：
Keyes, K. M.;Barnes, David M.;Bates, L. M.
通讯作者：
Bates, L. M.
DOI：
10.1111/j.1530-0277.1998.tb03611.x
发表时间：
1998-02-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Koob, GF;Roberts, AJ;Weiss, F
通讯作者：
Weiss, F