New Horizons: the value of UK Biobank to research on endocrine and metabolic disorders.
New Horizons: the value of UK Biobank to research on endocrine and metabolic disorders.
复制标题
DOI：
10.1210/clinem/dgac407
复制
发表时间：
2022-08-18
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
英国生物库是一项针对500,000名男性和女性的前瞻性研究，年龄在2006年至2010年期间从英国普通人群中招募，年龄在40岁至69岁之间。作为全球研究人员进行符合公众利益的健康研究的开放获取资源，英国生物库已经收集(并继续收集)大量关于遗传、生理、生活方式和环境因素的数据，并通过与行政电子健康记录的链接对健康状况进行长期跟踪。这项研究已经证明了它在研究常见内分泌和代谢性疾病的决定因素方面的独特价值。英国生物库被誉为英国健康研究的旗舰项目，随着疾病事件数量的增加，其重要性只会随着时间的推移而增加，这项研究将通过血液分析(如全基因组测序、代谢组学和蛋白质组学)、可穿戴技术(包括体力活动和心脏监测器)和身体成像(磁共振成像和双能X射线吸收法)的额外数据来增强。这一独特的研究资源可能会改变我们对许多内分泌和代谢疾病的病因、诊断和治疗的理解。
UK Biobank is an intensively characterized prospective study of 500 000 men and women, aged 40 to 69 years when recruited, between 2006 and 2010, from the general population of the United Kingdom. Established as an open-access resource for researchers worldwide to perform health research that is in the public interest, UK Biobank has collected (and continues to collect) a vast amount of data on genetic, physiological, lifestyle, and environmental factors, with prolonged follow-up of heath conditions through linkage to administrative electronic health records. The study has already demonstrated its unique value in enabling research into the determinants of common endocrine and metabolic diseases. The importance of UK Biobank, heralded as a flagship project for UK health research, will only increase over time as the number of incident disease events accrue, and the study is enhanced with additional data from blood assays (such as whole-genome sequencing, metabolomics, and proteomics), wearable technologies (including physical activity and cardiac monitors), and body imaging (magnetic resonance imaging and dual-energy X-ray absorptiometry). This unique research resource is likely to transform our understanding of the causes, diagnosis, and treatment of many endocrine and metabolic disorders.
登录
查看更多内容
影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
56.9
作者：
Akbari, Parsa;Gilani, Ankit;Sosina, Olukayode;Kosmicki, Jack A.;Khrimian, Lori;Fang, Yi-Ya;Persaud, Trikaldarshi;Garcia, Victor;Sun, Dylan;Li, Alexander;Mbatchou, Joelle;Locke, Adam E.;Benner, Christian;Verweij, Niek;Lin, Nan;Hossain, Sakib;Agostinucci, Kevin;Pascale, Jonathan, V;Dirice, Ercument;Dunn, Michael;Kraus, William E.;Shah, Svati H.;Chen, Yii-Der, I;Rotter, Jerome, I;Rader, Daniel J.;Melander, Olle;Still, Christopher D.;Mirshahi, Tooraj;Carey, David J.;Berumen-Campos, Jaime;Kuri-Morales, Pablo;Alegre-Diaz, Jesus;Torres, Jason M.;Emberson, Jonathan R.;Collins, Rory;Balasubramanian, Suganthi;Hawes, Alicia;Jones, Marcus;Zambrowicz, Brian;Murphy, Andrew J.;Paulding, Charles;Coppola, Giovanni;Overton, John D.;Reid, Jeffrey G.;Shuldiner, Alan R.;Cantor, Michael;Kang, Hyun M.;Abecasis, Goncalo R.;Karalis, Katia;Economides, Aris N.;Marchini, Jonathan;Yancopoulos, George D.;Sleeman, Mark W.;Altarejos, Judith;Della Gatta, Giusy;Tapia-Conyer, Roberto;Schwartzman, Michal L.;Baras, Aris;Ferreira, Manuel A. R.;Lotta, Luca A.
通讯作者：
Lotta, Luca A.
影响因子：
5.8
作者：
Fan, Xikang;Wang, Jiayu;Hang, Dong
通讯作者：
Hang, Dong
影响因子：
120.7
作者：
Larsson, Susanna C.;Burgess, Stephen;Michaelsson, Karl
通讯作者：
Michaelsson, Karl