Function of beta1 integrin in oral epithelia and tooth bud morphogenesis.
Function of beta1 integrin in oral epithelia and tooth bud morphogenesis.
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DOI：
10.1177/0022034509338008
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发表时间：
2009-06
影响因子：
7.6
通讯作者：
Raghavan S
中科院分区：
文献类型：
--
作者：
Chen B;Goodman E;Lu Z;Bandyopadhyay A;Magraw C;He T;Raghavan S
Integrin ϐ1 is critical for basement membrane organization and hair follicle morphogenesis in the skin epidermis; however, less is known about its function in the developing oral epithelium. Since the skin and oral epithelia share structural similarity, we hypothesized that ϐ1 integrin function would be critical for the normal development of oral epithelium and tooth buds. The conditional (oral mucosa-specific) ϐ1 integrin knockout (KO) mice displayed severe disruption of the basement membrane of the tongue epithelium and developing tooth buds. Interestingly, unlike the developing hair follicles, early morphological development of the KO molar tooth buds was normal. However, subsequent morphogenetic events, such as cusp formation, cervical loop down-growth, and ameloblast polarization, did not occur normally. Primary KO oral keratinocytes showed defective cell spreading and robust focal adhesions. Our studies indicate that ϐ1 integrin plays an essential role in the normal development of the oral epithelium and its appendages.
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影响因子：
7.5
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通讯作者：
Nieminen, P
影响因子：
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