Impact of the COVID-19 pandemic on the surveillance, prevention and control of antimicrobial resistance: a global survey.

Impact of the COVID-19 pandemic on the surveillance, prevention and control of antimicrobial resistance: a global survey.
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DOI:
10.1093/jac/dkab300
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发表时间:
2021-10-11
期刊:
The Journal of antimicrobial chemotherapy
影响因子:
--
通讯作者:
WHO AMR Surveillance and Quality Assessment Collaborating Centres Network
WHO AMR Surveillance and Quality Assessment Collaborating Centres Network
中科院分区:
其他
文献类型:
--
作者:
Tomczyk S;Taylor A;Brown A;de Kraker MEA;El-Saed A;Alshamrani M;Hendriksen RS;Jacob M;Löfmark S;Perovic O;Shetty N;Sievert D;Smith R;Stelling J;Thakur S;Vietor AC;Eckmanns T;WHO AMR Surveillance and Quality Assessment Collaborating Centres Network

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COVID-19大流行对卫生系统产生了重大影响。世卫组织抗菌素耐药性监测和质量评估合作中心网络开展了一项调查,以评估COVID-19对抗菌素耐药性监测、预防和控制的影响。2020年10月至12月,世卫组织全球抗微生物药物耐药性和使用监测系统(GLASS)国家协调中心完成了一份问卷,包括李克特量表和开放式问题。对数据进行了描述性分析,评估了收入/地区差异,并对自由文本问题进行了主题分析。不同收入水平的73个国家参与了调查。在2019冠状病毒病大流行期间,67%的受访者表示与抗微生物药物耐药性伙伴关系合作的能力有限;低收入和中等收入国家经常报告资金减少(LMICs; P < 0.01)。分别有71%、69%和64%报告抗菌素耐药性护理、医疗和公共卫生人员的可用性减少,而67%报告清洁人员的可用性稳定。大多数(58%)报告试剂/耗材减少,特别是低收入国家(P < 0.01)。报告的培养、选择性手术、慢性病住院和门诊人数减少以及ICU住院人数增加可能使AMR数据产生偏倚。报告的总体感染预防和控制(IPC)改善可能会降低AMR率,而某些不适当的IPC做法和抗菌药物处方的增加可能会增加AMR率。大多数国家还没有关于COVID-19引起的抗菌素耐药性变化的完整数据。这是首次探讨COVID-19对GLASS国家抗菌素耐药性的全球影响的调查。答复强调了有助于确保抗菌素耐药性仍然是全球卫生优先事项的重要行动,包括与GLASS合作以促进可靠的抗菌素耐药性监测数据,抓住机会制定更可持续的IPC规划,促进抗生素综合管理指导,利用增强的实验室能力和其他加强系统的努力。
The COVID-19 pandemic has had a substantial impact on health systems. The WHO Antimicrobial Resistance (AMR) Surveillance and Quality Assessment Collaborating Centres Network conducted a survey to assess the effects of COVID-19 on AMR surveillance, prevention and control. From October to December 2020, WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS) national focal points completed a questionnaire, including Likert scales and open-ended questions. Data were descriptively analysed, income/regional differences were assessed and free-text questions were thematically analysed. Seventy-three countries across income levels participated. During the COVID-19 pandemic, 67% reported limited ability to work with AMR partnerships; decreases in funding were frequently reported by low- and middle-income countries (LMICs; P < 0.01). Reduced availability of nursing, medical and public health staff for AMR was reported by 71%, 69% and 64%, respectively, whereas 67% reported stable cleaning staff availability. The majority (58%) reported reduced reagents/consumables, particularly LMICs (P < 0.01). Decreased numbers of cultures, elective procedures, chronically ill admissions and outpatients and increased ICU admissions reported could bias AMR data. Reported overall infection prevention and control (IPC) improvement could decrease AMR rates, whereas increases in selected inappropriate IPC practices and antimicrobial prescribing could increase rates. Most did not yet have complete data on changing AMR rates due to COVID-19. This was the first survey to explore the global impact of COVID-19 on AMR among GLASS countries. Responses highlight important actions to help ensure that AMR remains a global health priority, including engaging with GLASS to facilitate reliable AMR surveillance data, seizing the opportunity to develop more sustainable IPC programmes, promoting integrated antibiotic stewardship guidance, leveraging increased laboratory capabilities and other system-strengthening efforts.
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