ZNF804A genotype modulates neural activity during working memory for faces.
ZNF804A genotype modulates neural activity during working memory for faces.
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DOI：
10.1159/000344001
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发表时间：
2013
影响因子：
3.2
通讯作者：
Thome J
中科院分区：
文献类型：
--
作者：
Linden DE;Lancaster TM;Wolf C;Baird A;Jackson MC;Johnston SJ;Donev R;Thome J
精神分裂症（SZ）的遗传易感性已被认为会影响支持工作记忆（WM）和面孔加工的皮层系统。遗传成像研究将ZNF 804A基因上的SZ风险变体rs1344706通过WM期间功能性脑连接的改变与精神病联系起来，但没有研究ZNF 804A对具有面部处理组件的WM的影响。因此，我们研究了健康对照组rs1344706基因型与面部WM任务在功能性磁共振成像。我们认为，在rs1344706位点的变化将与类似的改变，患者以前测试使用相同的WM任务的面孔。rs1344706风险等位基因确实与右背外侧前额叶（rDLPFC）皮层的激活改变相关。我们确定rDLPFC以任务依赖的方式激活，这表明rs1344706基因型组之间的激活差异反映了任务处理的改变。此外，我们证明，rDLPFC区域表现出显着的体积重叠与rDLPFC，以前被报道在SZ患者的任务处理过程中被改变。研究结果支持之间的关联rs1344706和改变DLPFC活动在WM的脸。我们进一步建议，WM的面孔可能是一个有用的中间表型在精神病的遗传易感性的调查。
Genetic susceptibility to schizophrenia (SZ) has been suggested to influence the cortical systems supporting working memory (WM) and face processing. Genetic imaging studies link the SZ risk variant rs1344706 on the ZNF804A gene to psychosis via alterations in functional brain connectivity during WM, but no work has looked at the effects of ZNF804A on WM with face-processing components. We therefore investigated healthy controls that were genotyped for rs1344706 with a face WM task during functional magnetic resonance imaging. We suggested that variation at the rs1344706 locus would be associated with similar alterations as patients previously tested using the same WM task for faces. The rs1344706 risk allele was indeed associated with altered activation in the right dorsolateral prefrontal (rDLPFC) cortex. We established that the rDLPFC was activated in a task-dependent manner, suggesting that the differences in activation between rs1344706 genotype groups reflected alterations in task processing. Furthermore, we demonstrated that the rDLPFC region showed significant volumetric overlap with the rDLPFC which had previously been reported to be altered during task processing for patients with SZ. The findings support an association between rs1344706 and alterations in DLPFC activity during WM for faces. We further suggest that WM for faces may be a useful intermediate phenotype in the investigation of genetic susceptibility to psychosis.
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影响因子：
4.5
作者：
Karlsgodt, Katherine H.;Sanz, Jacqueline;van Erp, Theo G. M.;Bearden, Carrie E.;Nuechterlein, Keith H.;Cannon, Tyrone D.
通讯作者：
Cannon, Tyrone D.
影响因子：
2.6
作者：
Hall, Jeremy;Harris, Jonathan M.;Lawrie, Stephen M.
通讯作者：
Lawrie, Stephen M.
影响因子：
6.9
作者：
Broome, M. R.;Fusar-Poli, P.;McGuire, P. K.
通讯作者：
McGuire, P. K.
DOI：
10.1037/a0013895
发表时间：
2009-04-01
影响因子：
2.1
作者：
Jackson, Margaret C.;Wu, Chia-Yun;Raymond, Jane E.
通讯作者：
Raymond, Jane E.
增强愤怒面孔视觉短期记忆的神经相关性：一项 FMRI 研究。
影响因子：
3.7
作者：
Jackson, Margaret C.;Wolf, Claudia;Johnston, Stephen J.;Raymond, Jane E.;Linden, David E. J.
通讯作者：
Linden, David E. J.