Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis.
Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis.
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DOI：
10.1080/15592294.2023.2211361
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发表时间：
2023-12
期刊：
影响因子：
3.7
通讯作者：
Levy, Daniel
中科院分区：
文献类型：
--
作者：
Keshawarz, Amen;Joehanes, Roby;Ma, Jiantao;Lee, Gha Young;Costeira, Ricardo;Tsai, Pei-Chien;Masachs, Olatz M.;Bell, Jordana T.;Wilson, Rory;Thorand, Barbara;Winkelmann, Juliane;Peters, Annette;Linseisen, Jakob;Waldenberger, Melanie;Lehtimaeki, Terho;Mishra, Pashupati P.;Kahonen, Mika;Raitakari, Olli;Helminen, Mika;Wang, Carol A.;Melton, Phillip E.;Huang, Rae-Chi;Pennell, Craig E.;O'Sullivan, Therese A.;Ochoa-Rosales, Carolina;Voortman, Trudy;van Meurs, Joyce B. J.;Young, Kristin L.;Graff, Misa;Wang, Yujie;Kiel, Douglas P.;Smith, Caren E.;Jacques, Paul F.;Levy, Daniel
背景：饮食中摄入抗氧化剂，如维生素C和维生素E，可以防止氧化应激，也可能与DNA甲基化模式的改变有关。方法：我们荟萃分析了来自8个人群队列的11,866名参与者的表观基因组关联研究结果，以评估自我报告的饮食和补充维生素C和E的摄入量与DNA甲基化的关系。研究人员根据年龄、性别、体重指数、卡路里摄入量、血细胞比例、吸烟状况、饮酒情况和技术变量进行了调整。Meta分析的显著结果随后在基因集浓缩分析(GSEA)和表达数量性状甲基化(EQTM)分析中进行了评估。结果：在荟萃分析中，在FDR≤0.05时，4,656个CpG位点甲基化与维生素C摄入量显著相关。与维生素C相关的最重要的CpG位点(在FDReQTM0.01)在≤中富含与系统发展和细胞信号相关的途径，并与eQTM分析中富含在免疫反应中的基因的下游表达相关。此外，160cpG位点甲基化与维生素E摄入量显著相关，但对与维生素E相关的最重要的cpG位点甲基化的≤和eQTM分析没有发现所研究的任何生物途径的显著富集性。结论：我们确定了许多CpG位点与维生素C和E摄入量的显著关联，我们的结果表明维生素C的摄入量可能与系统发育和免疫反应有关。
Background: Dietary intake of antioxidants such as vitamins C and E protect against oxidative stress, and may also be associated with altered DNA methylation patterns. Methods: We meta-analysed epigenome-wide association study (EWAS) results from 11,866 participants across eight population-based cohorts to evaluate the association between self-reported dietary and supplemental intake of vitamins C and E with DNA methylation. EWAS were adjusted for age, sex, BMI, caloric intake, blood cell type proportion, smoking status, alcohol consumption, and technical covariates. Significant results of the meta-analysis were subsequently evaluated in gene set enrichment analysis (GSEA) and expression quantitative trait methylation (eQTM) analysis. Results: In meta-analysis, methylation at 4,656 CpG sites was significantly associated with vitamin C intake at FDR ≤ 0.05. The most significant CpG sites associated with vitamin C (at FDR ≤ 0.01) were enriched for pathways associated with systems development and cell signalling in GSEA, and were associated with downstream expression of genes enriched in the immune response in eQTM analysis. Furthermore, methylation at 160 CpG sites was significantly associated with vitamin E intake at FDR ≤ 0.05, but GSEA and eQTM analysis of the top most significant CpG sites associated with vitamin E did not identify significant enrichment of any biological pathways investigated. Conclusions: We identified significant associations of many CpG sites with vitamin C and E intake, and our results suggest that vitamin C intake may be associated with systems development and the immune response.
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影响因子：
16.6
作者：
Liu, Jun;Carnero-Montoro, Elena;van Duijn, Cornelia M.
通讯作者：
van Duijn, Cornelia M.
影响因子：
4.7
作者：
Ambrosini, G. L.;de Klerk, N. H.;Oddy, W. H.
通讯作者：
Oddy, W. H.
DOI：
10.2147/btt.s14417
发表时间：
2011
期刊：
Biologics : targets & therapy
影响因子：
--
作者：
Garcia-Bailo B;El-Sohemy A;Haddad PS;Arora P;Benzaied F;Karmali M;Badawi A
通讯作者：
Badawi A
影响因子：
1.9
作者：
Donkena KV;Young CY;Tindall DJ
通讯作者：
Tindall DJ
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y