A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing.
A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing.
复制标题
DOI：
10.1038/s41467-021-21964-0
复制
发表时间：
2021-03-15
影响因子：
16.6
通讯作者：
Wu X
中科院分区：
文献类型：
--
作者：
Zhang J;Zheng Y;Lee J;Hua J;Li S;Panchamukhi A;Yue J;Gou X;Xia Z;Zhu L;Wu X
皮肤伤口的有效愈合对我们的生存至关重要。虽然皮肤具有强大的再生潜力，但异常的伤口修复可能导致功能障碍和毁容的疤痕。皮肤瘢痕形成涉及ECM（细胞外基质）的过度沉积和错位、细胞构成增加和慢性炎症。转化生长因子-β（TGFβ）信号传导通过调节细胞增殖、迁移、ECM产生和免疫应答对伤口愈合发挥多效性作用。虽然阻断TGFβ信号传导可以减少组织纤维化和瘢痕形成，但全身性抑制TGFβ可能导致显著的副作用并抑制伤口再上皮化。在这项研究中，我们开发了一种基于集成光交联策略和具有脉冲释放TGF-β抑制剂的微胶囊平台的伤口敷料材料，以实现皮肤伤口的时空特异性。该材料增强皮肤伤口闭合，同时有效抑制小鼠皮肤伤口和大型动物临床前模型中的瘢痕形成。我们的研究提出了一种无瘢痕伤口修复的策略。功能障碍和毁容的疤痕可能是由于异常的伤口修复。在这里，作者开发了一种基于集成光交联策略和具有TGF-β抑制剂脉冲释放的微胶囊平台的伤口敷料材料，以实现无瘢痕伤口修复的时空特异性。
Effective healing of skin wounds is essential for our survival. Although skin has strong regenerative potential, dysfunctional and disfiguring scars can result from aberrant wound repair. Skin scarring involves excessive deposition and misalignment of ECM (extracellular matrix), increased cellularity, and chronic inflammation. Transforming growth factor-β (TGFβ) signaling exerts pleiotropic effects on wound healing by regulating cell proliferation, migration, ECM production, and the immune response. Although blocking TGFβ signaling can reduce tissue fibrosis and scarring, systemic inhibition of TGFβ can lead to significant side effects and inhibit wound re-epithelization. In this study, we develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for skin wounds. The material enhances skin wound closure while effectively suppressing scar formation in murine skin wounds and large animal preclinical models. Our study presents a strategy for scarless wound repair. Dysfunctional and disfiguring scars can result from aberrant wound repair. Here, the authors develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for scarless wound repair.
登录
查看更多内容
影响因子：
10.8
作者：
Cheung, RY;Kuba, R;Wu, XY
通讯作者：
Wu, XY
影响因子：
28.1
作者：
Li, Yuanyuan;Kong, Qingyao;Wu, Xiaoyang
通讯作者：
Wu, Xiaoyang
影响因子：
16.6
作者：
Giano, Michael C.;Ibrahim, Zuhaib;Medina, Scott H.;Sarhane, Karim A.;Christensen, Joani M.;Yamada, Yuji;Brandacher, Gerald;Schneider, Joel P.
通讯作者：
Schneider, Joel P.
影响因子：
3.5
作者：
Jude, EB;Blakytny, R;Ferguson, MWJ
通讯作者：
Ferguson, MWJ
影响因子：
2.9
作者：
Kloeters, Oliver;Tandara, Andrea;Mustoe, Thomas A.
通讯作者：
Mustoe, Thomas A.