High-Resolution Optical Coherence Tomography as an Adjunctive Tool in the Diagnosis of Corneal and Conjunctival Pathology.
High-Resolution Optical Coherence Tomography as an Adjunctive Tool in the Diagnosis of Corneal and Conjunctival Pathology.
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DOI：
10.1016/j.jtos.2015.02.001
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Karp CL
中科院分区：
文献类型：
--
作者：
Nanji AA;Sayyad FE;Galor A;Dubovy S;Karp CL
评价市售高分辨率光谱域光学相干断层扫描（HR OCT）器械在角膜和结膜病理诊断中的应用，重点关注恶性病变。该前瞻性病例系列纳入了71名患者的82只眼睛，其中包括10只正常眼睛、21只眼表鳞状瘤变（OSSN）、24只翼状胬肉或睑裂、3只淋巴瘤、18只色素性结膜病变（痣、扁平黑变病或黑色素瘤））和6只萨尔兹曼结节变性。使用摄影和HR OCT（RTVue，Optovue，Fremont，CA）对受试者进行成像。当有临床指征时，进行手术，并将组织病理学标本与OCT图像相关联。HR OCT可用于根据光学体征区分各种病变。具体而言，在OSSN中，HR OCT结果包括上皮增厚和高反射率，而翼状胬肉和睑裂斑显示较薄上皮下的上皮下肿块。在淋巴瘤中，观察到低反射、均匀的上皮下肿块。用HR OCT区分色素性病变更困难，但可以识别某些特征。痣和黑色素瘤的眼睛都表现出强烈的高反射基底上皮层和离散的上皮下病变，但可以通过痣中的囊肿和大多数黑色素瘤中的病灶下组织的强烈阴影来区分。我们发现，市售的HR OCT在眼表病变的诊断中是一种有用的非侵入性诊断工具。
To evaluate the use of a commercially-available, high-resolution, spectral-domain optical coherence tomography (HR OCT) device in the diagnosis of corneal and conjunctival pathologies, with a focus on malignant lesions. Eighty-two eyes of 71 patients were enrolled in this prospective case series, including 10 normal eyes, 21 with ocular surface squamous neoplasia (OSSN), 24 with a pterygium or pingueculum, 3 with lymphoma, 18 with pigmented conjunctival lesions (nevus, flat melanosis, or melanoma), and 6 with Salzmann’s nodular degeneration. Subjects were imaged using photography and HR OCT (RTVue, Optovue, Fremont, CA). When clinically indicated, surgery was performed and histopathologic specimens were correlated with OCT images. HR OCT was useful in differentiating among various lesions based on optical signs. Specifically, in OSSN, HR OCT findings included epithelial thickening and hyper-reflectivity, whereas pterygia and pinguecula showed a subepithelial mass under thinner epithelium. In lymphoma, a hypo-reflective, homogenous subepithelial mass was observed. Differentiating between pigmented lesions with HR OCT proved more difficult, but certain characteristics could be identified. Eyes with nevi and melanoma both displayed intensely hyper-reflective basal epithelial layers and discrete subepithelial lesions, but could be differentiated by the presence of cysts in nevi and intense shadowing of sublesional tissue in most melanomas. We found that a commercially-available HR OCT was a useful non-invasive adjunctive tool in the diagnosis of ocular surface lesions.
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影响因子：
13.7
作者：
Bianciotto, Carlos;Shields, Carol L.;Shields, Jerry A.
通讯作者：
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影响因子：
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通讯作者：
Shields, Carol L.
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