Quantitative MR imaging of two-pool magnetization transfer model parameters in myelin mutant shaking pup.
Quantitative MR imaging of two-pool magnetization transfer model parameters in myelin mutant shaking pup.
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DOI：
10.1016/j.neuroimage.2012.05.077
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发表时间：
2012-09
期刊：
影响因子：
5.7
通讯作者：
Field, Aaron S.
中科院分区：
文献类型：
--
作者：
Samsonov, Alexey;Alexander, Andrew L.;Mossahebi, Pouria;Wu, Yu-Chien;Duncan, Ian D.;Field, Aaron S.
关键词：
磁化传递（MT）成像定量评估脑白色物质疾病，通过其对大分子结合质子的敏感性，包括与髓鞘蛋白和脂质双层相关的质子。然而，通过MT比率（MTR）测量的传统MT对比度缺乏病理特异性，因为脱髓鞘、轴突损失、炎症和水肿都通过成像参数（特别是MTR与T1）和组织特征（例如轴突损失与脱髓鞘）之间的多重协方差直接和/或间接地影响MTR。在这项研究中，更复杂的MT现象建模（“定量”MT或qMT）应用于不太复杂的疾病模型（髓鞘突变体摇动[sh] pup，以髓鞘形成不足为特征，但既没有炎症也没有轴突丢失），以消除MR病理学“方程”两侧的协方差，并表征这些重要的关系，使其不受常见混淆的影响。在6只sh幼仔和5只年龄匹配的对照组中纵向采集qMT测量值，范围为3至16个月，并与组织学进行比较。qMT参数，结合池分数（f），是最有特色的患病和对照动物之间的f和纵向弛豫率R1跟踪髓鞘与正常老化，而MTR没有-大概是由于抵消MT和R1的影响。qMT成像提供了更准确且可能更特异的非侵入性组织表征。
Magnetization transfer (MT) imaging quantitatively assesses cerebral white matter disease through its sensitivity to macromolecule-bound protons including those associated with myelin proteins and lipid bilayers. However, traditional MT contrast measured by the MT ratio (MTR) lacks pathologic specificity as demyelination, axon loss, inflammation and edema all impact MTR, directly and/or indirectly through multiple covariances among imaging parameters (particularly MTR with T1) and tissue features (e.g. axon loss with demyelination). In this study, more complex modeling of MT phenomena (“quantitative” MT or qMT) was applied to a less complex disease model (the myelin mutant shaking [sh] pup, featuring hypomyelination but neither inflammation nor axon loss) in order to eliminate the covariances on both sides of the MR-pathology “equation” and characterize these important relationships free from the usual confounds. qMT measurements were acquired longitudinally in 6 sh pups and 5 age-matched controls ranging from 3 to 16 months of age and compared with histology. The qMT parameter, bound pool fraction (f), was the most distinctive between diseased and control animals; both f and longitudinal relaxation rate R1 tracked myelination with normal aging, whereas MTR did not—presumably owing to counterbalancing MT and R1 effects. qMT imaging provides a more accurate and potentially more specific non-invasive tissue characterization.
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