Multiexponential T2, magnetization transfer, and quantitative histology in white matter tracts of rat spinal cord.
Multiexponential T2, magnetization transfer, and quantitative histology in white matter tracts of rat spinal cord.
复制标题
DOI：
10.1002/mrm.22267
复制
发表时间：
2010-04
影响因子：
3.3
通讯作者：
Does, Mark D.
中科院分区：
文献类型：
--
作者：
Dula, Adrienne N.;Gochberg, Daniel F.;Valentine, Holly L.;Valentine, William M.;Does, Mark D.
多指数T2弛豫（MET2）和磁化传递（qMT）的定量MRI测量从6个样本的切除和固定的大鼠脊髓，并与定量组织学比较。MRI和组织学数据进行了分析，从六个白色物质束，其中每一个具有独特的显微解剖特征（轴突直径和髓鞘厚度，特别是），但相对恒定的体积分数的髓鞘。结果表明，MET2特征随显微解剖结构的变化而变化，而qMT特征基本保持不变。最常引用的MET 2指标，髓鞘水分数（MWF）在两个区域之间几乎相差2倍，髓鞘体积分数仅相差1.12%。基于定量组织学，对这种变化的拟议解释是房室间水交换，这导致MWF和T2值被低估，并且据推测，在轴突小且髓鞘薄的白色物质区域中是一个更大的因素。与MET 2观察结果相反，qMT指标在白色物质束中相对恒定，并得出结论，对房室间水交换相对不敏感。
Quantitative MRI measures of multi-exponential T2 relaxation (MET2) and magnetization transfer (qMT) were acquired from six samples of excised and fixed rat spinal cord and compared with quantitative histology. MRI and histology data were analyzed from six white matter tracts, each of which possessed unique micro-anatomical characteristics (axon diameter and myelin thickness, in particular) but a relatively constant volume fraction of myelin. The results indicated that MET2 characteristics varied substantially with variation of microanatomy while the qMT characteristics remained close to constant. The most-often cited MET2 metric, myelin water fraction (MWF) varied by almost a factor of 2 between two regions with myelin volume fractions that differed by only ≈ 12 %. Based on the quantitative histology, the proposed explanation for this variation was inter-compartmental water exchange, which caused the underestimation of MWF and T2 values and is, presumably, a greater factor in white matter regions where axons are small and myelin is thin. In contrast to the MET2 observations, qMT metrics were relatively constant across white matter tracts and concluded to be relatively insensitive to inter-compartmental water exchange.
登录
查看更多内容
影响因子：
3.3
作者：
Bjarnason, TA;Vavasour, IM;MacKay, AL
通讯作者：
MacKay, AL
影响因子：
9.9
作者：
Moore, GRW;Leung, E;Paty, DW
通讯作者：
Paty, DW
影响因子：
3.3
作者：
Does, MD;Snyder, RE
通讯作者：
Snyder, RE
影响因子：
3.3
作者：
Gochberg, Daniel F.;Gore, John C.
通讯作者：
Gore, John C.
影响因子：
2.9
作者：
BROWNSTEIN, KR;TARR, CE
通讯作者：
TARR, CE