Virus genomics: what is being overlooked?
Virus genomics: what is being overlooked?
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DOI：
10.1016/j.coviro.2022.101200
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发表时间：
2022-04
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
病毒是影响所有生命的各种生物实体。即使基因组大小有限，病毒也可以操纵、驱动、窃取和杀死它们的宿主。病毒基因组学领域，利用测序数据来了解病毒的能力，近年来已经出现了重大创新。然而，随着宏基因组测序和相关技术的进步，发现和利用病毒球的瓶颈已经成为基因组的分析而不是产生。随着宏基因组学迅速扩大可用数据，病毒基因组的重要组成部分和特征被忽视，滞后的数据库和生物信息学方法使问题更加复杂。尽管该领域正朝着积极的方向发展，但仍有一些值得注意的问题需要记住，从如何解释基于软件的病毒基因组预测到当前标准忽略了哪些信息。在这篇综述中，我们讨论了在病毒基因组学研究中继续前进的同时可能需要修改的惯例和意识形态。
Viruses are diverse biological entities that influence all life. Even with limited genome sizes, viruses can manipulate, drive, steal from, and kill their hosts. The field of virus genomics, using sequencing data to understand viral capabilities, has seen significant innovations in recent years. However, with advancements in metagenomic sequencing and related technologies, the bottleneck to discovering and employing the virosphere has become the analysis of genomes rather than generation. With metagenomics rapidly expanding available data, vital components of virus genomes and features are being overlooked, with the issue compounded by lagging databases and bioinformatics methods. Despite the field moving in a positive direction, there are noteworthy points to keep in mind, from how software-based virus genome predictions are interpreted to what information is overlooked by current standards. In this review, we discuss conventions and ideologies that likely need to be revised while continuing forward in the study of virus genomics.
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