Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry.
Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry.
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DOI：
10.1016/j.cjca.2023.06.001
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发表时间：
2024-01
影响因子：
6.2
通讯作者：
McCrindle, Brian W.
中科院分区：
文献类型：
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作者：
Harahsheh, Ashraf S.;Shah, Samay;Dallaire, Frederic;Manlhiot, Cedric;Khoury, Michael;Lee, Simon;Fabi, Marianna;Mauriello, Daniel;Tierney, Elif Seda Selamet;Sabati, Arash A.;Dionne, Audrey;Dahdah, Nagib;Choueiter, Nadine;Thacker, Deepika;Giglia, Therese M.;Truong, Dongngan T.;Jain, Supriya;Portman, Michael;Orr, William B.;Harris, Tyler H.;Szmuszkovicz, Jacqueline R.;Farid, Pedrom;McCrindle, Brian W.
儿童多系统炎症综合征（MIS-C）和川崎病（KD）患者具有重叠的临床特征。我们根据既往 SARS-CoV-2 感染的证据比较了患者的人口统计/临床表现、管理和结果。 ：国际 KD 注册中心 (IKDR) 招募了来自北美洲、中美洲和南美洲、欧洲、亚洲和中东地区的 KD 和 MIS-C 患者。先前感染的证据被定义为：阳性（+ve家庭接触或PCR/血清学阳性）、可能（PCR或血清学阴性但非两者均阴性的暗示MIS-C和/或KD的临床特征）、阴性（PCR和血清学阴性且无已知暴露）和未知（检测不完整且无已知暴露）。 ：在 2345 名入组患者中，1541 名 (66%) 患者的 SARS-CoV-2 状态为阳性，89 名患者 (4%) 为可能，404 名患者 (17%) 为阴性，311 名 (13%) 患者的 SARS-CoV-2 状态未知。各组之间的临床结果差异显着，阳性/可能组中有更多患者出现休克、进入重症监护室、接受正性肌力支持以及住院时间更长。关于心脏异常，阳性/可能组的患者左心室功能障碍的发生率较高，而阴性和未知组的患者冠状动脉异常更严重。结果：从 MIS-C 到 KD 似乎存在一系列临床特征，具有很大的异质性，一个主要的区分因素是先前急性 SARS CoV2 感染/暴露的证据。与 MIS-C 一致，SARS-CoV-2 阳性/疑似患者的症状更严重，需要更强化的治疗，心室功能障碍的可能性更大，但冠状动脉不良后果不太严重。
Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) and Kawasaki disease (KD) have overlapping clinical features. We compared demographics/clinical presentation, management, and outcomes of patients by evidence of prior SARS-CoV-2 infection. : The International KD Registry (IKDR) enrolled KD and MIS-C patients from sites from North, Central and South America, Europe, Asia and Middle East. Evidence of prior infection was defined as: Positive (+ve household contact or positive PCR/serology), Possible (suggestive clinical features of MIS-C and/or KD with negative PCR or serology but not both), Negative (negative PCR and serology and no known exposure), and Unknown (incomplete testing and no known exposure). : Of 2345 enrolled patients SARS-CoV-2 status was Positive for 1541 (66%) patients, Possible 89 (4%), Negative 404 (17%) and Unknown for 311 (13%) patients. Clinical outcomes varied significantly between the groups, with more patients in the Positive/Possible groups presenting with shock, having admission to Intensive Care, receiving inotropic support, and having longer hospital stays. Regarding cardiac abnormalities, patients in the Positive/Possible groups had a higher prevalence of left ventricular dysfunction, while patients in the Negative and Unknown groups had more severe coronary artery abnormalities. results : There appears to be a spectrum of clinical features from MIS-C to KD with a great deal of heterogeneity, and one primary differentiating factor is evidence for prior acute SARS CoV2 infection/exposure. SARS-CoV-2 Positive/Possible patients had more severe presentations and required more intensive management, with a greater likelihood of ventricular dysfunction but less severe coronary artery adverse outcomes, in keeping with MIS-C.
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影响因子：
6.2
作者：
Fridman, Michael D.;Tsoukas, Paul;Jeewa, Aamir;Yeung, Rae S. M.;Gamulka, Beth D.;McCrindle, Brian W.
通讯作者：
McCrindle, Brian W.
川崎疾病休克综合征与古典川崎病：与SARS-COV-2多系统炎症综合征的荟萃分析和比较。
DOI：
10.1016/j.cjca.2021.05.014
发表时间：
2021-10
期刊：
The Canadian journal of cardiology
影响因子：
--
作者：
Lamrani L;Manlhiot C;Elias MD;Choueiter NF;Dionne A;Harahsheh AS;Portman MA;McCrindle BW;Dahdah N
通讯作者：
Dahdah N
影响因子：
2.6
作者：
Fernández-Cooke E;Grasa CD;Domínguez-Rodríguez S;Barrios Tascón A;Sánchez-Manubens J;Anton J;Mercader B;Villalobos E;Camacho M;Navarro Gómez ML;Oltra Benavent M;Giralt G;Bustillo M;Bello Naranjo AM;Rocandio B;Rodríguez-González M;Núñez Cuadros E;Aracil Santos J;Moreno D;Calvo C;KAWA-RACE Study Group
通讯作者：
KAWA-RACE Study Group
影响因子：
3.6
作者：
Harahsheh, Ashraf S.;Sharron, Matthew P.;DeBiasi, Roberta L.
通讯作者：
DeBiasi, Roberta L.
影响因子：
16.6
作者：
通讯作者：
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